Buscar
Mostrando ítems 1-10 de 345
Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons
(2004)
Production of nitric oxide (NO) by glial cells has been proposed to mediate cytotoxic effects on neighboring neurons. Although extensive genetic data implicate the beta amyloid peptide (Aβ) in the neurodegenerative cascade ...
Cellular stress from excitatory neurotransmission contributes to cholesterol loss in hippocampal neurons aging in vitro
(Elsevier Inc, 2011-07)
After approximately 3 weeks in vitro, hippocampal neurons present many of the typical hallmarks accompanying neuronal aging in vivo, including accumulation of reactive oxygen species (ROS), lipofuscin granules, heterochromatic ...
Production of nerve growth factor by beta-amyloid-stimulated astrocytes induces p75(NTR)-dependent tau hyperphosphorylation in cultured hippocampal neurons
(WILEY-LISS, 2006-10)
Reactive astrocytes surround amyloid depositions and degenerating neurons in Alzheimer's disease (AD). It has been previously shown that P-amyloid peptide induces inflammatory-like responses in astrocytes, leading to ...
Contribution of NADPH oxidase to the establishment of hippocampal neuronal polarity in culture
(Company of Biologists Ltd., 2015)
Reactive oxygen species (ROS) produced by the NADPH oxidase (NOX) complex play
important physiological and pathological roles in neurotransmission and neurodegeneration,
respectively. However, the contribution of ROS to ...
Serotonin (5-HT) regulates neurite outgrowth through 5-HT1A and 5-HT7 receptors in cultured hippocampal neurons
(John Wiley and Sons Inc., 2014)
Serotonin (5-HT) production and expression of 5-HT receptors (5-HTRs) occur early during prenatal development. Recent evidence suggests that, in addition to its classical role as a neurotransmitter, 5-HT regulates neuronal ...
Arf6 is a negative regulator of axonal elongation in cultured rat hippocampal neurons
(2017)
The axonal elongation is a critical process for neuronal development that involves many cellular events, such
as endosome recycling, membrane trafficking and cytoskeletal remodeling. Members of several families of
GTPases ...
Protocol for evaluating neuronal polarity in murine models
(Cell Press, 2020-12)
The establishment of polarity is crucial for the physiology and wiring of neurons. Therefore, monitoring the axo-dendritic specification allows the mechanisms and signals associated with development, growth, and disease ...
Frizzled-5 Receptor Is Involved in Neuronal Polarity and Morphogenesis of Hippocampal Neurons
(2013)
The Wnt signaling pathway plays important roles during different stages of neuronal development, including neuronal
polarization and dendritic and axonal outgrowth. However, little is known about the identity of the ...
Further evidence for the neuroplastic role of cannabinoids: a study in organotypic hippocampal slice cultures
(Springer, 2015-08)
Endocannabinoid receptors CB1R and CB2R are present in the CNS and modulate synaptic activity. By using an in vitro model, two concentrations of CB1R agonist ACEA at 0.5 and 5 μM doses and CB1R antagonist AM251 at 1 and ...
Transforming growth factor-beta 1 produced by hippocampal cells modulates microglial reactivity in culture
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005)
Activated microglia produce superoxide anion (O-2(center dot-)) and nitric oxide (NO), both of which can be neurotoxic. To identify regulatory mechanisms that might modulate over-activation of microglia, we evaluated the ...