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Heparan sulfate and control of endothelial cell proliferation: increased synthesis during the S phase of the cell cycle and inhibition of thymidine incorporation induced by ortho-nitrophenyl-beta-D-xylose
(Elsevier B.V., 2004-08-04)
The effect of xylosides on the synthesis of [S-35]-sulfated glycosaminoglycans by endothelial cells in culture was investigated. Orthonitrophenyl-beta-D-xylose (10(-3)M) produces a dramatic enhancement on the synthesis of ...
Heparan sulfate and cell division
(Associação Brasileira de Divulgação Científica, 1999-05-01)
Heparan sulfate is a component of vertebrate and invertebrate tissues which appears during the cytodifferentiation stage of embryonic development. Its structure varies according to the tissue and species of origin and is ...
HEPARAN-SULFATE PROTEOGLYCAN AND CONTROL OF CELL-PROLIFERATION - ENHANCED SYNTHESIS INDUCED BY PHORBOL ESTER (PMA) DURING G(1)-PHASE
(Assoc Bras Divulg Cientifica, 1994-09-01)
The effect of phorbol 12-myristate-13-acetate (PMA), a tumor-promoting phorbol ester, on the synthesis of proteoglycans of endothelial cells in culture was investigated. This phorbol activates protein kinase C (PKC) when ...
Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling
(Assoc Bras Divulg Cientifica, 2006-02-01)
The syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of ...
Heparan sulfate-binding peptide promotes the deposition of proteoglycans in the extracellular matrix
(Wiley-Blackwell, 1997-06-15)
A synthetic peptide, which was shown to bind extracellular matrix heparan sulfate chains with a high degree of affinity and specificity [Colburn el al. (1996): Arch Biochem Biophys 325:129-138], has now been found to promote ...
Probing the interaction between heparan sulfate proteoglycan with biologically relevant molecules in mimetic models for cell membranes: A Langmuir film study
(Elsevier B.V., 2012-05-01)
Investigating the role of proteoglycans associated to cell membranes is fundamental to comprehend biochemical process that occurs at the level of membrane surfaces. in this paper, we exploit syndecan-4, a heparan sulfate ...
Differences in the expression of glycosaminoglycans in human fibroblasts derived from gingival overgrowths is related to TGF-beta up-regulation
(Informa HealthcareLondonInglaterra, 2010)
Biochemical and cytochemical characterization of extracellular proteoglycans in the inner circular smooth muscle layer of dog small intestine
(Taylor & Francis IncPhiladelphiaEUA, 2002)
Heparan sulfate potentiates leukocyte adhesion on cardiac fibroblast by enhancing Vcam-1 and Icam-1 expression
(Elsevier, 2018)
Cardiac fibroblasts (CF) act as sentinel cells responding to chemokines, cytokines and growth factors released in cardiac tissue in cardiac injury events, such as myocardial infarction (MI). Cardiac injury involves the ...