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Heparan sulfate and control of endothelial cell proliferation: increased synthesis during the S phase of the cell cycle and inhibition of thymidine incorporation induced by ortho-nitrophenyl-beta-D-xylose
(Elsevier B.V., 2004-08-04)
The effect of xylosides on the synthesis of [S-35]-sulfated glycosaminoglycans by endothelial cells in culture was investigated. Orthonitrophenyl-beta-D-xylose (10(-3)M) produces a dramatic enhancement on the synthesis of ...
HEPARAN-SULFATE PROTEOGLYCAN AND CONTROL OF CELL-PROLIFERATION - ENHANCED SYNTHESIS INDUCED BY PHORBOL ESTER (PMA) DURING G(1)-PHASE
(Assoc Bras Divulg Cientifica, 1994-09-01)
The effect of phorbol 12-myristate-13-acetate (PMA), a tumor-promoting phorbol ester, on the synthesis of proteoglycans of endothelial cells in culture was investigated. This phorbol activates protein kinase C (PKC) when ...
Heparan sulfate and cell division
(Associação Brasileira de Divulgação Científica, 1999-05-01)
Heparan sulfate is a component of vertebrate and invertebrate tissues which appears during the cytodifferentiation stage of embryonic development. Its structure varies according to the tissue and species of origin and is ...
Heparin and a cyclic octaphenol-octasulfonic acid (GL-522-Y-1) bind with high affinity to a 47-kDa protein from vascular endothelial cell surface and stimulate the synthesis and structural changes of heparan sulfate proteoglycan
(Elsevier B.V., 2001-07-01)
The effect of a cyclic octaphenol-octasulfonic acid (GL-522-Y-1), upon the synthesis of a heparan sulfate proteoglycan synthesized by endothelial cells (rabbit aorta and human umbilical vein) were studied. the cells were ...
Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling
(Assoc Bras Divulg Cientifica, 2006-02-01)
The syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of ...
Glycosaminoglycans in components of the rabbit eye: synthesis and characterization
(Swets Zeitlinger Publishers, 1999-08-01)
Purpose. To trace the eye components involved in proteoglycan synthesis and to characterize the sulfated glycosaminoglycans which are associated to these macromolecules.Methods. Sodium [S-35]-sulfate was injected intravitreally ...
Glycosaminoglycans in components of the rabbit eye: synthesis and characterization
(Swets Zeitlinger Publishers, 1999-08-01)
Purpose. To trace the eye components involved in proteoglycan synthesis and to characterize the sulfated glycosaminoglycans which are associated to these macromolecules.Methods. Sodium [S-35]-sulfate was injected intravitreally ...
EFFECT of MONENSIN ON the SULFATION of HEPARAN-SULFATE PROTEOGLYCAN FROM ENDOTHELIAL-CELLS
(Wiley-Blackwell, 1992-09-01)
Monensin is a monovalent metal ionophore that affects the intracellular translocation of secretory proteins at the level of trans-Golgi cisternae. Exposure of endothelial cells to monensin results in the synthesis of heparan ...
Heparan sulfate-binding peptide promotes the deposition of proteoglycans in the extracellular matrix
(Wiley-Blackwell, 1997-06-15)
A synthetic peptide, which was shown to bind extracellular matrix heparan sulfate chains with a high degree of affinity and specificity [Colburn el al. (1996): Arch Biochem Biophys 325:129-138], has now been found to promote ...
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?
(Associação Brasileira de Divulgação Científica, 1999-05-01)
The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous ...