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Editorial: Epitope discovery and Synthetic Vaccine design
(Frontiers Media Sa, 2018)
Immunoinformatic analysis of the whole proteome for vaccine design: An application to Clostridium perfringens
(Frontiers Media, 2022)
Clostridium perfringens is a dangerous bacterium and known biological warfare weapon associated with several diseases, whose lethal toxins can produce necrosis in humans. However, there is no safe and fully effective vaccine ...
Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production
(2016-03-03)
Novel vaccination approaches based on rational design of B- and T-cell epitopes - epitope-based vaccines - are making progress in the clinical trial pipeline. The epitope-focused recombinant protein-based malaria vaccine ...
In silico prediction of T- and B-cell epitopes in PmpD: First step towards to the design of a Chlamydia trachomatis vaccine
(Elsevier, 2018-04)
Background: Chlamydia trachomatis is the most common sexually transmitted bacterial infection globally. Currently, there are no vaccines available despite the efforts made to develop a protective one. Polymorphic membrane ...
A bioinformatics tool for epitope-based vaccine design that accounts for human ethnic diversity : Application to emerging infectious diseases
(2015-03-03)
Background: Peptide vaccination based on multiple T-cell epitopes can be used to target well-defined ethnic populations. Because the response to T-cell epitopes is restricted by HLA proteins, the HLA specificity of T-cell ...
QSPR-Perturbation Models for the Prediction of B-Epitopes from Immune Epitope Database: A Potentially Valuable Route for Predicting “In Silico” New Optimal Peptide Sequences and/or Boundary Conditions for Vaccine Development
(Springer, 2016-12)
In the present study, three different physicochemical molecular properties for peptides were calculated using the program MARCH-INSIDE: atomic polarizability, partition coefficient, and polarity. These measures were used ...
Development of bióinformatics tools to analyse peptide-protein interactións: immunoinformatics applicatións in next generatión vaccine design
(2017)
Epitope-based vaccines (EVs) make use of short, antigen-derived peptides corresponding
to epitopes that are administered lo trigger a protective humoral (B-cell epitopes) and/or
cellular (T-cell epitopes) immune response. ...
Computer-aided design of T-cell epitope-based vaccines : Addressing population coverage
(2015-10-01)
Epitope-based vaccines (EVs) make use of short antigen-derived peptides corresponding to immune epitopes, which are administered to trigger a protective humoral and/or cellular immune response. EVs potentially allow for ...
Sampling SARS-CoV-2 Proteomes for Predicted CD8 T-Cell Epitopes as a Tool for Understanding Immunogenic Breadth and Rational Vaccine Design
(Frontiers in Bioscience, 2021-02-19)
Predictive models for vaccine design have become a powerful and necessary resource for the expeditiousness design of vaccines to combat the ongoing SARS-CoV-2 global pandemic. Here we use the power of these predicted models ...