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Chiral HPLC analysis of donepezil, 5-O-desmethyl donepezil and 6-O-desmethyl donepezil in culture medium: application to fungal biotransformation studies
(SPRINGER HEIDELBERGHEIDELBERG, 2012)
An high performance liquid chromatography (HPLC) method for the enantioselective determination of donepezil (DPZ), 5-O-desmethyl donepezil (5-ODD), and 6-O-desmethyl donepezil (6-ODD) in Czapek culture medium to be applied ...
Efeitos do uso agudo do donepezil sobre habilidade visuoespaciais de voluntários jovens sadios
(Universidade Federal de São Paulo (UNIFESP), 2009-01-01)
Rationale: Drugs such as donepezil that increase the availability of acetylcholine (Ach) are known to improve cognition. However, there is no consensus as to the acute nootropic potential of this drug when administered to ...
Effects of donepezil on behavioral manifestations of thalamic infarction: A single-case observation
(2011)
Objective: To examine the effect of donepezil for the treatment of cognitive and behavioral disorders associated with thalamic lesions in a 45-year-old male who suffered an infarct in the left thalamus. Background: Recent ...
The Effect of Donepezil on Arousal Threshold and Apnea-Hypopnea Index A Randomized, Double-Blind, Cross-Over Study
(Amer Thoracic Soc, 2016)
Rationale: Obstructive sleep apnea (OSA) has multiple pathophysiological causes. A low respiratory arousal threshold (ArTh) and a high loop gain (unstable ventilatory control) can contribute to recurrent respiratory events ...
Antagonism of morphine-induced central respiratory depression by donepezil in the anesthetized rabbit
(Sociedad de Biología de Chile, 2007)
Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits
(Sociedad de Biología de Chile, 2009)
Cholinesterase inhibitors for Alzheimer's disease: Multitargeting strategy based on anti-Alzheimer's drugs repositioning
(Bentham Science Publishers, 2019)
Acute effects of donepezil in healthy young adults underline the fractionation of executive functioning
(Sage Publications Ltd, 2011-11-01)
The cholinergic system is involved in the modulation of both bottom-up and top-down attentional control. Top-down attention engages multiple executive control processes, but few studies have investigated whether all or ...
Estudos visando a síntese total da (±)-galantamina e síntese de híbridos donepezil-ácido lipóico
(Universidade Federal de Minas GeraisUFMG, 2017-11-29)
Alzheimer's disease (AD) is a neurodegenerative pathogenesischaracterized by cognitive impairment in patients, such as short-term memory impairment, speech and language loss, impaired motor coordination, and patient learning ...
Potencial terapêutico do donepezil em modelos animais de discinesia orofacial: aspectos indutores e fatores de risco
(Universidade Federal de São Paulo (UNIFESP), 2013)
A discinesia tardia (DT) e considerada nao apenas o mais importante efeito colateral decorrente da administracao prolongada de antipsicoticos, mas tambem o principal disturbio iatrogenico do movimento. Caracterizada por ...