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Dynamic RNA structures in the dengue virus genome
(Landes Bioscience, 2011)
Dengue virus is an important human pathogen that belongs to the Flaviviridae family. The viral genome is a single molecule of RNA of positive polarity that plays multiple roles during the viral life cycle. Besides encoding ...
Virulence factor RNA transcript expression in the Leishmania Viannia subgenus: Influence of species, isolate source, and Leishmania RNA virus-1
(Springer, 2019)
Background: Leishmania RNA virus-1 (LRV1) is a double-stranded RNA virus identified in 20-25% of Viannia - species endemic to Latin America, and is believed to accelerate cutaneous to mucosal leishmaniasis over time. Our ...
Novel ATP-independent RNA annealing activity of the dengue virus NS3 helicase
(Public Library Of Science, 2012-04)
The flavivirus nonstructural protein 3 (NS3) bears multiple enzymatic activities and represents an attractive target for antiviral intervention. NS3 contains the viral serine protease at the N-terminus and ATPase, RTPase, ...
vtRNA2-1/nc886 produces a small RNA that contributes to its tumor suppression action through the microRNA pathway in prostate cancer
(MDPI, 2020)
vtRNA2-1 is a vault RNA initially classified as microRNA precursor hsa-mir-886 and recently proposed as “nc886”, a new type of non-coding RNA involved in cancer progression acting as an oncogene and tumor suppressor gene ...
Coevolution of an aminoacyl-tRNA synthetase with its tRNA substrates
(NATL ACAD SCIENCES, 2003-11-25)
Glutamyl-tRNA synthetases (GluRSs) occur in two types, the discriminating and the nondiscriminating enzymes. They differ in their choice of substrates and use either tRNA(Glu) or both tRNA(Glu) and tRNA(Gln). Although most ...
Genome cyclization as strategy for flavivirus RNA replication
(Elsevier Science, 2008-09)
Long-range and local RNA-RNA contacts in viral RNA genomes result in tertiary structures that modulate the function of enhancers, promoters, and silencers during translation, RNA replication, and encapsidation. In the case ...
Isolation of high quality RNA from soil-grown Ilex paraguariensis roots suitable for next-generation sequencing and gene expression analyses
(Southern Cross Publ, 2017-07)
Extraction of high quality RNA is a prerequisite for downstream application in functional genomics analyses. However, the extraction and purification of pure nucleic acids from root tissues is generally difficult due to ...
Isolation of high quality RNA from soil-grown Ilex paraguariensis roots suitable for next-generation sequencing and gene expression analyses
(Southerm Cross, 2017-07)
Extraction of high quality RNA is a prerequisite for downstream application in functional genomics analyses. However, the extraction and purification of pure nucleic acids from root tissues is generally difficult due to ...