Article
Full-length infectious clone of a low passage dengue virus serotype 2 from Brazil
Registro en:
SANTOS, J. J. DA S. et al. Full-length infectious clone of a low passage dengue virus serotype 2 from Brazil. Memorias Do Instituto Oswaldo Cruz, v. 110, n. 5, p. 677–683, ago. 2015.
1678-8060
10.1590/0074-02760150053
Autor
Santos, Jefferson José da Silva
Magalhães, Tereza
Silva Junior, José Valter Joaquim
Silva, Andréa Nazaré Monteiro Rangel da
Cordeiro, Marli Tenório
Gil, Laura Helena Vega Gonzales
Resumen
Full-length dengue virus (DENV) cDNA clones are an invaluable tool for many studies, including those on the development of attenuated or chimeric vaccines and on host-virus interactions. Furthermore, the importance of low passage DENV infectious clones should be highlighted, as these may harbour critical and unique strain-specific viral components from field-circulating isolates. The successful construction of a functional Brazilian low passage DENV serotype 2 full-length clone through homologous recombination reported here supports the use of a strategy that has been shown to be highly useful by our group for the development of flavivirus infectious clones and replicons.
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