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Prion pathogenesis is independent of Caspase-12
(2007)
The pathogenic mechanism(s) underlying neurodegenerative diseases associated with protein misfolding is unclear. Several studies have implicated ER stress pathways in neurodegenerative conditions, including prion disease, ...
Single CpG island methylation is not sufficient to maintain the silenced expression of CASPASE-8 apoptosis-related gene among women with epithelial ovarian cancer
(Elsevier B.V., 2014-02-01)
Despite impressive research efforts, the biology of epithelial ovarian cancer (EOC) remains poorly understood and alterations in the expression of CASPASE-8 contribute to a worse tumor prognosis. This study assesses the ...
Involvement of major components from sporothrix schenckii cell wall in the caspase-1 activation, nitric oxide and cytokines production during experimental sporotrichosis
(Springer, 2015-02-01)
Sporotrichosis is a chronic infection caused by the dimorphic fungus Sporothrix schenckii, involving all layers of skin and the subcutaneous tissue. The role of innate immune toll-like receptors 2 and 4 in the defense ...
Expressão de topoisomerase II alfa e de caspase-3 ativada em lesão intra-epitelial cervical escamosa de baixo grau
(Universidade Federal de São Paulo (UNIFESP), 2008-03-26)
Purpose: To evaluate the correlation between the expression of topoisomerase II alpha, active caspase-3 and infection with human papillomavirus in low-grade cervical intraepithelial lesion and in the normal cervix, and ...
Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle
(BioScientifica, 2006-09-01)
Apoptosis is associated with the regression of the corpus luteum (CL) in many species. Since caspases play a central role in apoptosis, we studied several initiators (-2, -8, and -9) and the main effector (-3) caspase in ...
New Views on the Misconstrued: Executioner Caspases and Their Diverse Non-apoptotic Roles
(Cell Press, 2015-11)
Initially characterized for their roles in apoptosis, executioner caspases have emerged as important regulators of an array of cellular activities. This is especially true in the nervous system, where sublethal caspase ...
High concentrations of anti-caspase-8 antibodies in Chilean patients with type 1 diabetes
(Elsevier, 2011)
Introduction: Deregulation of apoptosis across the Fas–FasL pathway is an increasingly relevant phenomenon
in the pathogenic mechanisms associated with autoimmune diseases. Caspase-8 initiates the
activation of the ...