Buscar

Mostrando ítems 1-10 de 38

Docking Applied to the Study of Inhibitors of c-Met Kinase

Gavernet, Luciana; Palestro, Pablo Hernán; Bruno Blanch, Luis Enrique (2012)

Docking and quantitative structure-activity relationship studies for 3-fluoro-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yloxy)aniline, 3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline, and 4-(4-amino-2-fluorophenoxy)-2-pyridinylamine derivatives as c-Met kinase inhibitors

Caballero, J.; Quiliano, M.; Alzate-Morales, J.H.; Zimic, M.; Deharo, E. (SPRINGER, 2012)

Docking and quantitative structure-activity relationship studies for 3-fluoro-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yloxy)aniline, 3-fluoro-4-(1H- pyrrolo[2,3-b]pyridin-4-yloxy)aniline, and 4-(4-amino-2-fluorophenoxy)-2- pyridinylamine derivatives as c-Met kinase inhibitors

Autor desconocido (Springer, 2011)

We have performed docking of 3-fluoro-4-(pyrrolo[2,1-f][1,2,4]triazin-4- yloxy)aniline (FPTA), 3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline (FPPA), and 4-(4-amino-2-fluorophenoxy)-2-pyridinylamine (AFPP) derivatives ...

Docking and quantitative structure-activity relationship studies for 3-fluoro-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yloxy)aniline, 3-fluoro-4-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)aniline, and 4-(4-amino-2-fluorophenoxy)-2-pyridinylamine derivatives as c-met kinase inhibitors

Autor desconocido (SPRINGER, 2011)

MET Signaling Pathways, Resistance Mechanisms, and Opportunities for Target Therapies

Rivas, Solange; Marín, Arnaldo; Samtani, Suraj; González, Evelin; Armisén, Ricardo (2022)

The MET gene, known as MET proto-oncogene receptor tyrosine kinase, was first identified to induce tumor cell migration, invasion, and proliferation/survival through canonical RAS-CDC42-PAK-Rho kinase, RAS-MAPK, PI3K-AKT-mTOR, ...

Docking and quantitative structure-activity relationship studies for 3-fluoro-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yloxy)aniline, 3-fluoro-4-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)aniline, and 4-(4-amino-2-fluorophenoxy)-2-pyridinylamine derivatives as c-met kinase inhibitorsJOURNAL OF COMPUTER-AIDED MOLECULAR DESIGNJ COMPUT AID MOL DES

Caballero, Julio; Quiliano, Miguel; Alzate-Morales, Jans H.; Zimic, Mirko; Deharo, Eric (SPRINGER, 2011)

Determinantes moleculares de resposta e resistencia aos inibidores da tirosina quinase (TKI) em pacientes com carcinoma de pulmão não pequenas celulas (CPNPC) com mutações no gene do recptor do fator de crescimento epidermico (EGFR)Molecular determinants of response and resistance to tyrosine kinase inhibitors (TKIs in patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) gene mutation

Costa, Daniel Botelho ([s.n.], 2008)

In vitro isolation of variants of herpes simplex virus attenuated with altered thymidine kinase and DNA polymerase genes using carrageenans as selection agents

Mateu, Cecilia Gabriela; Artuso, María Carolina; Pujol, Carlos Alberto; Linero, Florencia Natalia; Scolaro, Luis Alberto; Carlucci, Maria Josefina (Springer, 2017-05)

Natural polysaccharides known as carrageenans are potent and selective inhibitors of herpes simplex virus through blocking the interaction of the virus with the cellular receptor. Passaging the virus in vitro in the presence ...

Oligosaccharyltransferase inhibition reduces receptor tyrosine kinase activation and enhances glioma radiosensitivity

Barontini, Marta Beatriz; López Sambrooks, Cecilia; Quijano, Amanda; Mark Saltzman, W.; Contessa, Joseph (American Association for Cancer Research, 2019-01)

Purpose: Parallel signaling reduces the effects of receptor tyrosine kinase (RTK)–targeted therapies in glioma. We hypothesized that inhibition of protein N-linked glycosylation, an endoplasmic reticulum co- and posttranslational ...

Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence

University of Texas Southwestern Medical Center; University of Texas Health; Universidade Estadual Paulista (UNESP); Eugene McDermott Center for Human Growth and Development; Mayo Clinic; Veterans Affairs North Texas Health Care System (2021-12-01)

Glioblastomas (GBM) are routinely treated with ionizing radiation (IR) but inevitably recur and develop therapy resistance. During treatment, the tissue surrounding tumors is also irradiated. IR potently induces senescence, ...