Articulo
Docking Applied to the Study of Inhibitors of c-Met Kinase
Autor
Gavernet, Luciana
Palestro, Pablo Hernán
Bruno Blanch, Luis Enrique
Institución
Resumen
Quinoxaline derivatives were studied as inhibitors of c-Met kinase, a receptor associated with high tumor grade and poor prognosis in a number of human cancers. In this paper we used docking methodologies to predict the binding conformation of a set of quinoxalines and to explain the differences of biological activities previously reported. Facultad de Ciencias Exactas