Buscar
Mostrando ítems 1-10 de 544
Modelling and optimization of the cephalosporin C production bioprocess in a fed-batch bioreactor with invert sugar as substrate
(Elsevier B.V., 1999-08-01)
Cephalosporin C production process optimization was studied based on four experiments carried out in an agitated and aerated tank fermenter operated as a fed-batch reactor. The microorganism Cephalosporium acremonium ATCC ...
Modelling and optimization of the cephalosporin C production bioprocess in a fed-batch bioreactor with invert sugar as substrate
(Elsevier B.V., 1999-08-01)
Cephalosporin C production process optimization was studied based on four experiments carried out in an agitated and aerated tank fermenter operated as a fed-batch reactor. The microorganism Cephalosporium acremonium ATCC ...
Tracking Control of Optimal Profiles in a Nonlinear Fed-Batch Bioprocess under Parametric Uncertainty and Process Disturbances
(American Chemical Society, 2018-07)
The problem of optimal profiles tracking control under uncertainties for a nonlinear fed-batch bioprocess is addressed in this paper. Based on the results reported by Pantano et al. [ Ind. Eng. Chem. Res. 2017, 56, 6043], ...
Multivariable Control for Tracking Optimal Profiles in a Nonlinear Fed-Batch Bioprocess Integrated with State Estimation
(American Chemical Society, 2017-05)
This paper aims to solve the problem of tracking optimal profiles for a nonlinear multivariable fed-batch bioprocess by a simple but efficient closed-loop control technique based on a linear algebra approach. In the proposed ...
A Bayesian Approach to Run-to-Run Optimization of Animal Cell Bioreactors Using Probabilistic Tendency Models
(American Chemical Society, 2014-08)
Increasing demand for recombinant proteins (including monoclonal antibodies) where time to market is critical could benefit from the use of model-based optimization of cell viability and productivity. Owing to the complexity ...
Vero cell upstream bioprocess development for the production of viral vectors and vaccines
The Vero cell line is considered the most used continuous cell line for the production of viral vectors and
vaccines. Historically, it is the first cell line that was approved by the WHO for the production of human vaccines. ...