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Inoculation site from a cutaneous melanoma patient treated with an allogeneic therapeutic vaccine: A case report
(Frontiers Media S.A., 2015-04)
We have developed a therapeutic vaccine consisting of a mixture of lethally-irradiated allogeneic cutaneous melanoma cell lines with BCG and GM-CSF as adjuvants. The CSF-470 vaccine is currently being assayed in a Phase ...
The role of CD8+ T cells during allograft rejection
(Associação Brasileira de Divulgação Científica, 2002-11-01)
Organ transplantation can be considered as replacement therapy for patients with end-stage organ failure. The percent of one-year allograft survival has increased due, among other factors, to a better understanding of the ...
CD40 activation of BCP-ALL cells generates IL-10-producing, IL-12-defective APCs that induce allogeneic T-cell anergy
(American Society of Hematology, 2004-12)
The use of leukemia cells as antigenpresenting cells (APCs) in immunotherapy is critically dependent on their capacity to initiate and sustain an antitumor-specific immune response. Previous studies suggested that pediatric ...
Treatment of colon cancer cells with 5-fluorouracil can improve the effectiveness of RNA-transfected antitumor dendritic cell vaccine
(Spandidos Publ Ltd, 2017-07-01)
Non-cytotoxic concentrations of selected chemotherapeutic agents amplify the antigen presentation capacity of dendritic cells (DCs) and are able to increase the immunogenicity of the colon cancer cell lineage HCT-116, as ...
Failure of Cell-Mediated Effector Mechanisms in Lung Cancer
(National Cancer Institute (JNCI), 2017)
Experimental evidence pointing to the bidirectional interaction between the immune system and the thyroid axis
(Elsevier, 2000-12)
Among the many examples of neuroendocrine-immune system interactions the relationship between the thyroid axis and the immune function has yet to be clearly established. Here we studied the influence of thyroid hormones ...