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Structural antitumoral activity relationships of synthetic chalcones
(2009)
Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction ...
Structure-antioxidant activity relationships of flavonoids isolated from the resinous exudate of Heliotropium sinuatum
(Pergamon-Elsevier Science Ltd., 2005)
A structure-activity relationship study of quinone compounds with trypanocidal activity
(Elsevier B.V., 2005-04-01)
A set of 25 quinone compounds with anti-trypanocidal activity was studied by using the density functional theory (DFT) method in order to calculate atomic and molecular properties to be correlated with the biological ...
A structure-activity relationship study of quinone compounds with trypanocidal activity
(Elsevier B.V., 2005-04-01)
A set of 25 quinone compounds with anti-trypanocidal activity was studied by using the density functional theory (DFT) method in order to calculate atomic and molecular properties to be correlated with the biological ...
Structure-activity relationship of mastoparan analogs: effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity
(Elsevier B. V., 2015-05-02)
In this study, a series of mastoparan analogs were engineered based on the strategies of Ala and Lys scanning in relation to the sequences of classical mastoparans. Ten analog mastoparans, presenting from zero to six Lys ...
Synthesis, leishmanicidal activity, structural descriptors and structure-activity relationship of quinoline derivatives
(Future Sci Ltd, 2018-09-01)
Aim: Considering the epidemiology of leishmaniasis, the emergence of resistant parasites to the approved drugs, and severe clinical manifestations, the development of novel leishmanicidal molecules has become of considerable ...
A structure-activity relationship study of quinone compounds with trypanocidal activity
(Elsevier B.V., 2014)
Insights on the structure-activity relationship of peptides derived from Sticholysin II
(Wiley-Blackwell, 2018-09-01)
Sticholysin II (StII) is a pore-forming actinoporin from the sea anemone Stichodactyla helianthus. A mechanistic model of its action has been proposed: proteins bind to cell membrane, insert their N-termini into the lipid ...
Quantum-Chemical Structure-Activity Relationships in Carbamate Insecticides
(Kluwer Academic Publishers, 1995-01-10)
A non-empirical Quantitative Structure-Activity Relationship (QSAR) method is employed
to analyze the reversible complex formation during the reaction of phenyl-N-methylcarbamates with
the enzyme acetylcholinesterase. ...