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Role of ROX1, SKN7, and YAP6 stress transcription factors in the production of secondary metabolites in xanthophyllomyces dendrorhous
(MDPI, 2022)
Xanthophyllomyces dendrorhous is a natural source of astaxanthin and mycosporines. This
yeast has been isolated from high and cold mountainous regions around the world, and the production
of these secondary metabolites ...
TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors
(Nature Publishing Group, 2015-05)
The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes. We have now ...
Yeast oxidative stress response - Influences of cytosolic thioredoxin peroxidase I and of the mitochondrial functional state
(Blackwell PublishingOxfordInglaterra, 2006)
Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells
(2019)
Gastric carcinomas (GC) are heterogeneous tumors, composed of a subpopulation of cluster of differentiation-44 (CD44)+ tumorigenic and chemoresistant cancer stem cells (CSC). YAP1 and TAZ oncoproteins (Y/T) interact with ...
Leukaemia Inhibitory Factor (LIF) inhibits cancer stem cells tumorigenic properties through hippo kinases activation in gastric cancer
(2020)
Cancer stem cells (CSCs) present chemo-resistance mechanisms contributing to tumour
maintenance and recurrence, making their targeting of utmost importance in gastric cancer (GC)
therapy. The Hippo pathway has been ...
TAZ Controls Helicobacter pylori-Induced Epithelial–Mesenchymal Transition and Cancer Stem Cell-Like Invasive and Tumorigenic Properties
(2020)
Helicobacter pylori infection, the main risk factor for gastric cancer (GC), leads to an epithelial–mesenchymal transition (EMT) of gastric epithelium contributing to gastric cancer stem cell (CSC) emergence. The Hippo ...