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Design, synthesis and biological evaluation of quinoxaline compounds as anti-HIV agents targeting reverse transcriptase enzyme
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2020-02)
Infection by human immunodeficiency virus still represents a continuous serious concern and a global threat to human health. Due to appearance of multi-resistant virus strains and the serious adverse side effects of the ...
Inhibition by stabilization: Targeting the Plasmodium falciparum aldolase-TRAP complex
(BioMed Central, 2015-08)
Background: Emerging resistance of the malaria parasite Plasmodium to current therapies underscores the critical importance of exploring novel strategies for disease eradication. Plasmodium species are obligate intracellular ...
Atendimento odontológico do paciente com doença falciforme: proposta de intervenção para a UAPS Eustáquio de Queiroz do município de Pirapora/MG
(Universidade Federal de Minas GeraisUFMG, 2014-06-07)
Sickle cell disease is the most common genetic disease of man and most widespread in the world. The condition is more common in black individuals, with a tendency to reach an increasingly significant portion of the population, ...
Existe associação do uso de implantes mamários texturizados com linfoma anaplásico de células grandes?Is there an association between the use of textured breast implants with anaplastic large cell lymphoma?
(Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde, 2020)
Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines
(Bentham Science Publishers, 2013-09)
Rho GTPases play a key role in the regulation of multiple essential cellular processes, including actin dynamics, gene transcription and cell cycle progression. Aberrant activation of Rac1, a member of Rho family of small ...
Atenção integral ao portador de doença falciforme: plano de ação na Estratégia Saúde da Família
(Universidade Federal de Minas GeraisUFMG, 2014-06-14)
Sickle cell disease , the most common hereditary disease in Brazil , is a public health issue . In Brazil the disease is prevalent among blacks and browns and rarely among whites . It is characterized by the predominance ...