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Hypotension caused by therapeutic doses of venlafaxine: case report and proposed pathophysiological mechanisms
(SAGE PUBLICATIONS LTD, 2008)
Although venlafaxine is usually associated with modest increases in blood pressure and not so often clinical hypertension, there are a few reported cases of hypotension related to overdoses of this specific antidepressant. ...
Proconvulsant effects of high doses of venlafaxine in pentylenetetrazole-convulsive rats
(Associação Brasileira de Divulgação Científica, 2002-04-01)
Venlafaxine, an atypical antidepressant drug, has been used to treat several neurological disorders, presenting excellent efficacy and tolerability. Clinical seizures after venlafaxine treatment have occasionally been ...
Venlafaxine-induced damage to seminiferous epithelium, spermiation, and sperm parameters in rats: A correlation with high estrogen levels
(2020-01-01)
Background: Venlafaxine (selective serotonin and norepinephrine reuptake inhibitor) use has increased worldwide. However, the impact of venlafaxine on testes and sperm parameters has not been investigated. Objectives: We ...
Postnatal development of rats exposed to fluoxetine or venlafaxine during the third week of pregnancy
(Associação Brasileira de Divulgação Científica, 1999-01-01)
The aim of the present study was to compare the toxic effects of fluoxetine (F) (8 and 16 mg/kg) and venlafaxine (V) (40 and 80 mg/kg) administered during the third week of pregnancy on early development of rats. Both ...
Evidence for an antihyperalgesic effect of venlafaxine in vincristine-induced neuropathy in rat
(Elsevier, 2003)
Venlafaxine, a new antidepressant with fewer side effects, could be of interest to reduce neuropathic pain following antineoplasic drug treatment. In the present study, we demonstrated that venlafaxine inhibits hyperalgesia ...
Early response to venlafaxine antidepressant correlates with lower ACTH levels prior to pharmacological treatment
(2006)
A link between stressful life events and development or exacerbation of depression has been established via a large body of evidence. An alteration in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis in ...
Chiral HPLC analysis of venlafaxine metabolites in rat liver microsomal preparations after LPME extraction and application to an in vitro biotransformation study
(SPRINGER HEIDELBERG, 2010)
A three-phase LPME (liquid-phase microextraction) method for the enantioselective analysis of venlafaxine (VF) metabolites (O-desmethylvenlafaxine (ODV) and N-desmethylvenlafaxine (NDV) in microsomal preparations is described ...
Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method
(Elsevier Science, 2013-09)
Venlafaxine hydrochloride (VEN) is an antidepressant drug widely used for the treatment of depression. The purpose of this study was to carry out the preparation and solid state characterization of the pure polymorphs ...
Lactational exposure to venlafaxine provokes late repercussions on reproductive parameters in male rat offspring
(Wiley-Blackwell, 2022-09-10)
Exposure to selective serotonin reuptake inhibitors can affect hormone-dependent processes, such as the brain sexual differentiation. Because the use of these antidepressants cause concern during lactation, we evaluated ...