Artículo de revista
Evidence for an antihyperalgesic effect of venlafaxine in vincristine-induced neuropathy in rat
Fecha
2003Registro en:
Brain Research, Volumen 980, Issue 1, 2018, Pages 117-120
00068993
10.1016/S0006-8993(03)02946-9
Autor
Marchand, Fabien
Alloui, Abdelkrim
Pelissier Serrano, Teresa
Hernández, Alejandro
Authier, Nicolas
Alvarez, Pedro
Eschalier, Alain
Ardid, Denis
Institución
Resumen
Venlafaxine, a new antidepressant with fewer side effects, could be of interest to reduce neuropathic pain following antineoplasic drug treatment. In the present study, we demonstrated that venlafaxine inhibits hyperalgesia in a new rat model of neuropathy induced by the antineoplasic drug vincristine, and exerts its effect preferentially via supraspinal and spinal mechanisms. © 2003 Elsevier B.V. All rights reserved.