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Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses
(American Association for the Advancement of Science, 2016)
Construção de híbridos dos interferons humanos beta e alfa2: papel das alfa-helices e alças na atividade biológica
(Universidade Federal de Minas GeraisUFMG, 2005-05-13)
Interferons are proteins involved in the organism defense processes, derived from cellular responses to microorganisms, tumors and antigens and are classified in type I, comprehending the IFN-, IFN-, IFN-, IFN-, IFN- and ...
Endogenous accumulation of IFN-gamma in IFN-gamma-R-/- mice increases resistance to B16F10-Nex2 murine melanoma: a model for direct IFN-gamma anti-tumor cytotoxicity in vitro and in vivo
(Taylor & Francis As, 2002-06-01)
Syngeneic IFN-gamma - / - and IRF-1 - / - mice are very sensitive to B16F10-Nex2 murine melanoma cells implanted subcutaneously. in contrast, IFN-gamma-R - / - (GRKO) mice are remarkably resistant to tumor development. ...
Genetic lesions of type i interferon signalling in human antiviral immunity
The concept that type I interferons (IFN-I) are essential to antiviral immunity
derives from studies on animal models and cell lines. Virtually all pathogenic
viruses have evolved countermeasures to IFN-I restriction, ...
Imunidade inata ao vírus da dengue: um estudo do interferon do tipo IInnate immunity to dengue virus: a study of the type I interferon
(Centro de Pesquisas Aggeu Magalhães, 2015)
Type I IFN deficiency: an immunological characteristic of severe COVID-19 patients
Recently, a paper published in Science by Hadjadj et al. reported
that type I interferon (IFN) deficiency, could be a hallmark of
severe coronavirus disease 2019 (COVID-19) caused by severe
acute respiratory syndrome ...
Dengue: desenvolvimento de ferramentas moleculares e caracterização de cepas virais quanto a inibição da sinalização do Interferon do tipo I (IFN-I)Dengue: development of molecular tools and characterization of viral strains inhibition of signaling as the type I interferon (IFN-I)
(Centro de Pesquisas Aggeu Magalhães, 2016)
Stage-specific role of interferon-gamma in experimental autoimmune encephalomyelitis and multiple sclerosis
(Frontiers Media, 2015)
The role of interferon (IFN)-gamma in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), has remained as an enigmatic paradox for more than 30 years. Several studies attribute ...