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Concomitant tumor resistance
(Elsevier Ireland, 2012-11)
Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host is resistant to the growth of secondary tumor implants. This phenomenon has been described in human and animal systems and it can be generated ...
Stability analysis and numerical simulations via fractional calculus for tumor dormancy models
(2019-06-30)
Fractional calculus is a field of mathematics in considerable expansion and has been understood as a tool with a wide range of applications, including in biological systems. Cancer dormancy is a state in which cancer cells ...
Glypican-3 (GPC3) inhibits metastasis development promoting dormancy in breast cancer cells by p38 MAPK pathway activation
(Elsevier Gmbh, 2020-08)
GPC3 is a proteoglycan involved in the control of proliferation and survival, which has been linked to several tumor types. In this respect, we previously demonstrated that normal breast tissues exhibit high levels of GPC3, ...
Modelos matemáticos de dinâmica tumoral com EDO de ordem inteira e não inteira
(Universidade Estadual Paulista (Unesp), 2020-06-15)
Modelos matemáticos são estratégias cada vez mais comuns no estudo de processos biológicos, e aqueles envolvendo equações diferenciais, sejam do tipo ordinárias, parciais ou fracionárias, estão entre os mais usados. O ...
Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells
(MDPI AG, 2016)
Tumor angiogenesis is widely recognized as one of the hallmarks of cancer. Consequently, during the last decades the development and testing of commercial angiogenic inhibitors has been a central focus for both basic and ...
The acceleration of metastases after tumor removal and the paradoxical phenomenon of concomitant tumor resistance
(Noble Research, 2018-10)
Although surgical extirpation of tumors is usually clinically recommended, tumor removal may entail an undesired side effect: the risk of accelerating the growth of metastases. This effect may account for the relatively ...
Overcoming dormancy in Bauhinia scandens seeds
(2020-08-01)
Bauhinia scandens, an ornamental climbing vine, recently introduced in Brazil, in 2006 which has been gaining prominence due to its anti-tumor medicinal properties. A common feature amongst species of the Fabaceae family ...
Concomitant tumor resistance: The role of tyrosine isomers in the mechanisms of metastases control
(American Association for Cancer Research, 2012-03)
Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. Although previous studies indicated that T-cell-dependent processes ...
Dormência do câncer: modelos matemáticos e simulações numéricas
(Universidade Estadual Paulista (Unesp), 2017-02-16)
O câncer é uma das principais causas de morbidade e mortalidade em todo o mundo. Um problema que atinge muitos pacientes diagnosticados com câncer é a recidiva, que pode ocorrer anos após uma aparente remissão completa da ...
Tyrosine isomers mediate the classical phenomenon of concomitant tumor resistance
(American Association for Cancer Research, 2011-11)
Concomitant tumor resistance (CR) is a phenomenon originally described in 1906 in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. Although recent studies have indicated ...