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The identification of translesion DNA synthesis regulators: inhibitors in the spotlight
(Elsevier, 2015-08)
Over the past half-century, we have become increasingly aware of the ubiquity ofDNA damage. Under the constant exposure to exogenous and endogenous genomic stress, cells must attempt to replicate damaged DNA. The encounter ...
The p21 and PCNA partnership: a new twist for an old plot
(Taylor & Francis, 2008-12)
The contribution of error-prone DNA polymerases to the DNA damage response has been a subject of great interest in the last decade. Error-prone polymerases are required for translesion DNA synthesis (TLS), a process that ...
Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome
(Elsevier, 2014-02)
Ultraviolet (UV)-induced DNA damage are removed by nucleotide excision repair (NER) or can be tolerated by specialized translesion synthesis (TLS) polymerases, such as Polη. TLS may act at stalled replication forks or ...
UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability
(Oxford University Press, 2013-05)
Although many genotoxic treatments upregulate the cyclin kinase inhibitor p21, agents such as UV irradiation trigger p21 degradation. This suggests that p21 blocks a process relevant for the cellular response to UV. Here, ...
Beyond interstrand crosslinks repair: contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA
(Elsevier Science, 2018-03)
Biallelic mutations of FANCD2 and other components of the Fanconi Anemia (FA) pathway cause a disease characterized by bone marrow failure, cancer predisposition and a striking sensitivity to agents that induce crosslinks ...
The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53.
(MDPI, 2018-07)
The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53.Gottifredi V1, Wiesmüller L2.The tumor suppressor p53 is a transcriptional factor broadly mutated in cancer. Most inactivating and gain ...
Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells
(Oxford University Press, 2017-02)
Genome lesions trigger biological responses that help cells manage damaged DNA, improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses lesions that block replicative polymerases, avoiding ...
Biochemical studies with DNA polymerase beta and DNA polymerase beta-PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance
(Elsevier B.V., 2008-11-01)
Mammalian DNA polymerase p is a nuclear enzyme involved in the base excision and single-stranded DNA break repair pathways. in trypanosomatids, this protein does not have a defined cellular localization, and its function ...
Síntese translesão e reparo de DNA em Trypanosoma cruzi: caracterização funcional da DNA polimerase kappa e análise da remoção de lesões no DNA nuclear e mitocondrial
(Universidade Federal de Minas GeraisUFMG, 2011-04-27)
Trypanosoma cruzi is the causative agent of Chagas disease, and during its life cycle it is subjective to several genotoxic agents, which can lead to mutations, cell division blockage or even cell death. The major mechanisms ...
DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression
(National Academy Of Sciences, 2016-07)
DNA damage tolerance facilitates the progression of replication forks that have encountered obstacles on the template strands. It involves either translesion DNA synthesis initiated by proliferating cell nuclear antigen ...