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Phosphorylation regulates functions of ZEB1 transcription factor
(Wiley-liss, Div John Wiley & Sons Inc, 2016-03)
ZEB1 transcription factor is important in both development and disease, including many TGFβ-induced responses, and the epithelial-to-mesenchymal transition (EMT) by which many tumors undergo metastasis. ZEB1 is differentially ...
Involvement of Renal Corpuscle microRNA Expression on Epithelial-to-Mesenchymal Transition in Maternal Low Protein Diet in Adult Programmed Rats
(Public Library ScienceSan FranciscoEUA, 2013)
CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer
(Company of Biologists, 2011-05)
During progression of breast cancer, CCN6 protein exerts tumor inhibitory functions. CCN6 is a secreted protein that modulates the insulin-like growth factor-1 (IGF-1) signaling pathway. Knockdown of CCN6 in benign mammary ...
El factor transcripcional ZEB1 promueve el desarrollo tumoral y la resistencia a quimioterapéuticos en células de cáncer prostático
(Universidad de Chile, 2017)
Introducción: El cáncer de próstata (CaP) en Chile representa la tercera patología oncológica más común en hombres y la segunda en causas de muerte por cáncer. Recientemente se ha visto que uno de los mecanismos involucrados ...
MicroRNAs that regulate the expression of the transcription factors SNAIL, SLUG, ZEB1 and TWIST repress the invasion, migration and cell proliferation in breast cancerMicroRNAs que regulan la expresión de SNAIL, SLUG, ZEB1 y TWIST reprimen la invasión, migración y proliferación celular en cáncer de mama
(2020)
Breast cancer is classified in different tumor subtypes, each one with different molecular and clinical traits, specially in relation to the development of metastasis and overall survival. On the other hand, metastasis is ...
Hypoxic Melanoma Cells Deliver microRNAs to Dendritic Cells and Cytotoxic T Lymphocytes through Connexin-43 Channels
(MDPI, 2020)
Alterations in microRNA (miRNA) profiles, induced by tumor microenvironment stressors, like hypoxia, allow cancer cells to acquire immune-resistance phenotypes. Indeed, hypoxia-induced miRNAs have been implicated in cancer ...
Glypican-3 induces a mesenchymal to epithelial transition in human breast cancer cells
(Impact journals, 2016-09)
Breast cancer is the disease with the highest impact on global health, beingmetastasis the main cause of death. To metastasize, carcinoma cells must reactivate a latent program called epithelial-mesenchymal transition ...
Efecto de la sobreexpresión de miR-145 más miR-23b, en la proliferación, migración e invasión de líneas celulares de cáncer ovárico epitelial : bases para el desarrollo de una nanoformulación
(Universidad de Chile, 2023)
Introducción: El cáncer ovárico epitelial (COE) es una de las neoplasias ginecológicas más letales. Este se caracteriza por la aparición tardía e inespecífica de síntomas y por una quimiorresistencia en estadios avanzados. ...