Buscar
Mostrando ítems 1-10 de 55
Structural characteristics of the TPR Protein-Hsp90 interaction: A new target in biotechnology
(Bentham Science Publishers, 2018)
Nature employs multiple repeat protein scaffolds in order to promote proteinprotein interactions. In this sense, TPR proteins participate in different natural pathways, especially in diverse processes of eukaryotic cells. ...
Purification and characterization of a novel and conserved TPR-domain protein that binds both Hsp90 and Hsp70 and is expressed in all developmental stages of Leishmania major
(Elsevier B.V., 2021-03-01)
Heat shock proteins (Hsps) are involved in several important aspects of the cell proteostasis. Hsp90 interacts with at least a tenth of the cell proteome helping a large number of proteins to fold correctly. Hsp90 function ...
Differential regulation of the glucocorticoid receptor nucleocytoplasmic shuttling by TPR-domain proteins
(Elsevier Science, 2021-05)
A dimer of the heat-shock protein of 90-kDa (Hsp90) represents the critical core of the chaperone complex associated to the glucocorticoid receptor (GR) oligomer. The C-terminal end of the Hsp90 dimer shapes a functional ...
Human Hsp70/Hsp90 Organizing Protein (Hop) D456G Is a Mixture of Monomeric and Dimeric Species
(Bentham Science Publ LtdSharjahEmirados Árabes Unidos, 2010)
Molecular chaperone activity and biological regulatory actions of the TPR-domain immunophilins FKBP51 and FKBP52
(Bentham Science Publishers, 2014-05)
Immunophilins comprise a family of intracellular proteins with peptidyl-prolyl-(cis/trans)-isomerase activity. These foldases are abundant, ubiquitous, and able to bind immunosuppressant drugs, from which the term immunophilin ...
TPR-Domain immunophilin FKBP51 is a major mitochondrial protein that protects cells against oxidative stress
(American Society For Biochemistry And Molecular Biology, 2011-07-05)
Confocal microscopy images revealed that the tetratricopeptide repeat motif (TPR) domain immunophilin FKBP51 shows colocalization with the specific mitochondrial marker MitoTracker. Signal specificity was tested with ...
Bacillus subtilis RapA Phosphatase Domain Interaction with Its Substrate, Phosphorylated Spo0F, and Its Inhibitor, the PhrA Peptide
(American Society For Microbiology, 2012-03)
Rap proteins in Bacillus subtilis regulate the phosphorylation level or the DNA-binding activity of response regulators such as Spo0F, involved in sporulation initiation, or ComA, regulating competence development. Rap ...
Human mitochondrial import receptor Tom70 functions as a monomer
(Portland Press LtdLondonInglaterra, 2010)
The emerging role of TPR-domain immunophilins in the mechanism of action of action of steroid receptors
(AgiAL Publishing Group, 2014-11-30)
In the absence of ligand, some members of nuclear receptor family such as corticosteroid receptors are primarily located in the cytoplasm, and they rapidly accumulate in the nucleus upon ligand-binding. Other members of ...