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Modelagem do fenótipo de diabetes em Nauphoeta cinerea usando estreptozotocina: Foco no metabolismo da glicose no cérebro
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2021-05-16)
The brain is highly dependent on adequate glucose catabolism, but changes in brain glucose transport are well documented in hyperglycemic conditions. Recent evidence of “hyperglycemic memory" further suggests that chronic ...
Análise dos efeitos de RAP2A sobre a ativação do fator de transcrição NF-kappaB na via de sinalização celular dos receptores do tipo Toll (TLRs)
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Biologia CelularUFMG, 2014-07-24)
Pathogen recognition, a key event for the initiation of innate immune response, is
mediated by pattern-recognition receptors (PRRs) such as toll-like receptors (TLRs).
Cell signaling triggered through TLRs leads to the ...
Expression and functionality of Toll-like receptor 3 in the megakaryocytic lineage
(Wiley Blackwell Publishing, Inc, 2015-05)
Background: In addition to their key role in hemostasis, platelets and megakaryocytes regulate immune and inflammatory responses, in part through their expression of Toll-like receptors (TLRs). Among the TLRs, TLR3 recognizes ...
Functional Toll-like receptor 4 expressed in lactotrophs mediates LPS-induced proliferation in experimental pituitary hyperplasia
(Elsevier Inc, 2013-11)
Toll like receptor 4 (TLR4) has been characterized for its ability to recognize bacterial endotoxin lipopolysaccharide (LPS). Considering that infections or inflammatory processes might contribute to the progression of ...
Expression and activation of intracellular receptors TLR7, TLR8 and TLR9 in peripheral blood monocytes from HIV-infected patients.
(2013-07-09)
Introduction. TLR´s play a role in host defense in HIV infection
recognizing the viral DNA or RNA. Their activation induces a signaling
pathway that includes the proteins MyD88, IRAK4, TRAF6 and
the transcription factor ...
Análise do papel da metformina na via insulínica, não-insulínica e inflamatória
(Universidade Federal de UberlândiaBRPrograma de Pós-graduação em Genética e BioquímicaCiências BiológicasUFU, 2016)
Participación de la vía NF-kB en la respuesta a péptidos derivados de la proteína GP5 del virus PRRS
(Universidad Michoacana de San Nicolás de Hidalgo, 2022-12)
The nuclear factor-κB (NF-κB) signaling pathway plays an important role during viral infection and disease development. PRRSV infections can cause abnormal activation of NF-κB, which subsequently results in an immunosuppressed ...
RasGEF1b: localização celular de seus domínios e papel regulador negativo sobre a ativação de NF-kappaB
(Universidade Federal de Minas GeraisUFMG, 2011-07-29)
The guanine nucleotide exchange factor RasGEF1b is a protein encoded by a gene whose expression is strongly induced in response to stimuli with Toll-like receptor (TLR) agonists. RasGEF1b is found localized at the early ...