Two-­pore domain potassium (K2P) channels trigger the background K+ currents in mammalian cells. K2P channels are separated into six subfamilies based on their structural and functional properties. The acid-­sensitive ...

TASK-­‐3 is a two-­‐pore domain potassium (K2P) channel highly expressed in hippocampus, cerebellum and cortex. TASK-­‐3 regulates neurotransmitter functions as well as the mediating effect of the neurotransmitter activa ...

K+ channels allow the selective transfer of K+ ions inside or outside of the cell. Within this family we find K2P channels, with four transmembrane segments and two pore domains per subunit to form a functional dimer. These ...

Potassium (K+) channels are part of one of the most abundant family of transmembrane proteins. K+ channels allow the selective transfer of K+ ions inside or outside of the cell. Within this family we find K2P channels, ...

The two-pore domain potassium (K2P) channel TASK-3 is a highly expressed in hippocampus, cerebellum and cortical areas of the brain. Besides regulating neurotransmitter functions, TASK-3 has an oncogenic potential and it ...

Two-­pore domain potassium (K2P) channels are expressed as functional dimers in the central nervous system, cardiovascular system, genitourinary system and gastrointestinal system. They are related with several pathologies ...

Two-­‐pore domain potassium (K2P) channels underlie the background K+ currents in mammalian cells. They can be segregated into six subfamilies based on their structure and functional properties. The acid-­‐ sensitive TAS ...

A1899 is a potent and a highly selective blocker of the two-­pore domain potassium (K2P) channel TASK-­1. It acts as an antagonist blocking the K+ flux and binds to TASK-­1 in the inner cavity, showing activity in the ...