Ponencia
Understanding the structural mechanism of selective blockers of pH-gated K2P channels
Fecha
2018Institución
Resumen
Two-‐pore
domain
potassium
(K2P)
channels
underlie
the
background
K+
currents
in
mammalian
cells.
They
can
be
segregated
into
six
subfamilies
based
on
their
structure
and
functional
properties.
The
acid-‐
sensitive
TASK-‐1
and
TASK-‐3
channels
belong