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Tailored Multi-Target Agents: Applications and Design Considerations
(Bentham Science Publishers, 2016-03)
In contrast to the one target-one drug model, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in ...
Network pharmacology and epilepsy
(Springer, 2016)
In contrast with the reductionist “one gene, one target, one drug” approach, network pharmacology proposes the use of multi-target therapies, a strategy that seems particularly suitable to treat disorders of complex etiology, ...
The efficiency of multi-target drugs: A network approach
(Springer, 2020)
Multi-target agents have attracted great attention in the last 15 years, as they are expected to provide more efficacious and safer therapeutic solutions, less prone to drug resistance phenomena. They thus seem particularly ...
The variation of comonomers feeding profile to design the distribution of chains composition for the optimization of the mechanical properties in copolymer systems
(2009)
Context. Determining the parameters of massive stars is crucial to understand many processes in galaxies and the Universe, since these objects are important sources of ionization, chemical enrichment and momentum. 10m class ...
Actividad antibacteriana y citotóxica de bioconjugados de péptidos Ib-M con nanopartículas de óxido de hierro contra Escherichia coli O157:H7 y células vero
(Facultad Ciencias de la SaludMaestría en Investigación en Enfermedades Infecciosas, 2019-06-14)
Escherichia coli O157:H7 es el patógeno más común aislado en brotes relacionados con alimentos cárnicos, está directamente asociado con el desarrollo del Síndrome Hemolítico Urémico (SHU) y posee gran capacidad para ...
Thermo-sensitive actuator capabilities assessment of a composite material based on a two-way shape memory semicrystalline polymer
(Universidad Nacional de ColombiaMedellín - Arquitectura - Maestría en ConstrucciónEscuela de construcciónFacultad de ArquitecturaMedellín, ColombiaUniversidad Nacional de Colombia - Sede Medellín, 2018)
Evidence suggests that energy efficiency is one of the most crucial factors to be addressed in XXI century by building industry, and the study of the building envelope, which includes passive systems of dynamic activation ...