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Protein kinases in the photic signaling of the mammalian circadian clock
(Yale School of Medicine, 2019-06-27)
Circadian clocks drive biological rhythms in physiology and behavior, providing a selective advantage by enabling organisms to synchronize to the 24 h environmental day. This process depends on lightdark transitions as the ...
Suprachiasmatic astrocytes modulate the circadian clock in response to TNF-α
(American Association of Immunologists, 2013-11)
The immune and the circadian systems interact in a bidirectional fashion. The master circadian oscillator, located in the suprachiasmatic nuclei (SCN) of the hypothalamus, responds to peripheral and local immune stimuli, ...
Role of astrocytes in the immune-circadian signaling
(IOS Press, 2013-10)
The mammalian circadian system controls biological rhythms by means of a central biological clock located in the suprachiasmatic nuclei (SCN) as well as diverse peripheral oscillators located throughout the body. Besides ...
Circadian disruption induced by tumor development in a murine model of melanoma
(Taylor & Francis, 2021-09)
The circadian system induces oscillations in most physiological variables, with periods close to 24 hours. Dysfunctions in clock-controlled body functions, such as sleep disorders, as well as deregulation of clock gene ...
Suprachiasmatic Nucleus and Subordinate Brain Oscillators: Clock Gene Desynchronization by Neuroinflammation
(2018-03-01)
Objective: The clock genes Period (per) 1 and 2 are essential components in the generation and adjustment of biological circadian rhythms by the suprachiasmatic nucleus (SCN). Both genes are also rhythmically present in ...
Disruption of light-induced c-Fos immunoreactivity in the suprachiasmatic nuclei of chronic epileptic rats
(Elsevier B.V., 1996-09-27)
Photic stimulation during specific day periods may induce Fos oncoprotein expression within the ventrolateral part of the suprachiasmatic nucleus (SCN) in the hypothalamus of rodents. This phenomenon appears to be a major ...
Dysregulation of circadian rhythms in autism spectrum disorders
(2019-01-01)
Background: The alterations in neurological and neuroendocrine functions observed in the autism spectrum disorder (ASD) involves environmentally dependent dysregulation of neurodevelopment, in interaction with multiple ...
Role of G-Substrate in the NO/cGMP/PKG Signal Transduction Pathway for Photic Entrainment of the Hamster Circadian Clock
(SAGE Publications, 2021-01)
The mammalian circadian clock at the hypothalamic suprachiasmatic nuclei (SCN) entrains biological rhythms to the 24- h cyclic environment, by encoding light-dark transitions in SCN neurons. Light pulses induce phase shifts ...
CCL2 mediates the circadian response to low dose endotoxin
(Elsevier, 2016-05)
The mammalian circadian system is mainly originated in a master oscillator located in the suprachiasmatic nuclei (SCN) in the hypothalamus. Previous reports from our and other groups have shown that the SCN are sensitive ...
N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
(Wiley, 2013-12)
Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the ...