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Peptide synthesis: chemical or enzymatic
(Pontificia Universidad Católica de Valparaíso, 2007)
Advances in metal-mediated solid-phase synthesis of heterocyclic compounds
(Springer, 2017)
While heterocycles are a key feature frequently found in compounds with pharmaceutical or agrochemical interest, the combination between solidsupported synthesis and organometallic chemistry has demonstrated to be a helpful ...
Synthesis of a Small Library of Imidazolidin-2-ones using Gold Catalysis on Solid Phase
(American Chemical Society, 2016-08)
An efficient and high-yielding solid phase synthesis of a small library of imidazolidin-2-ones and imidazol-2-ones was carried out employing a high chemo- and regioselective gold-catalyzed cycloisomerization as a key step. ...
Regioselective Incorporation of Backbone Constraints Compatible with Traditional Solid-Phase Peptide Synthesis
(American Chemical Society, 2012-12)
A protected aldehyde was attached via a twocarbon spacer to a peptide backbone amide nitrogen during a traditional Merrifield solid-phase synthesis. Acid-mediated unmasking of the aldehyde triggered the regioselective ...
Synthesis of multicyclic β-Lactam derivatives via solid-phase- generated ketenes
(American Chemical Society, 2010-09)
An efficient approach for the solid-phase synthesis of multicyclic â-lactam derivatives is described. The key step is the cycloaddition reaction between an immobilized ketene and different cyclic imines to afford the ...
Recent advances in the solid-phase synthesis of N-heteroaromatic five membered rings
(Research Signpost, 2007)
Combinatorial chemistry and related high-speed syntheses are powerful tools for the discovery of new drugs. In particular, solid-phase organic synthesis (SPOS) is being widely used for the preparation of a large number of ...
Peptidomimetics via Iminium Ion Chemistry on Solid Phase: Single, Fused, and Bridged Heterocycles
(Springer Berlin Heidelberg, 2015-12)
Iminium ion chemistry represents a versatile transformation capable of introducing structurally diverse constraints into peptide backbones. The compatibility of iminium ion chemistry with traditional solid-phase peptide ...
Peptidomimetics via Iminium Ion Chemistry on Solid Phase: Single, Fused, and Bridged Heterocycles
(Springer, 2015)
Iminium ion chemistry represents a versatile transformation capable of introducing structurally diverse constraints into peptide backbones. The compatibility of iminium ion chemistry with traditional solid-phase peptide ...