Peptidomimetics via Iminium Ion Chemistry on Solid Phase: Single, Fused, and Bridged Heterocycles

Abstract

Iminium ion chemistry represents a versatile transformation capable of introducing structurally diverse constraints into peptide backbones. The compatibility of iminium ion chemistry with traditional solid-phase peptide synthesis methods enables the introduction of constraints without requiring solution-phase synthesis. This chapter describes the introduction of constrained molecular scaffolds composed of single, fused, and bridged heterocycles into peptide backbones.