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pkCSM: Predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures
(American Chemical Society, 2016)
Small molecules to perform big roles: The search for Parkinson's and Huntington's disease therapeutics
(2023)
Neurological motor disorders (NMDs) such as Parkinson's disease and Huntington's disease are characterized by the accumulation and aggregation of misfolded proteins that trigger cell death of specific neuronal populations ...
Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line
(Sociedad de Biología de Chile, 2008)
Interaction of the small-molecule kinase inhibitors tofacitinib and lapatinib with membranes
(Elsevier Science, 2020-11)
Lapatinib and tofacitinib are small-molecule kinase inhibitors approved for the treatment of advanced or metastatic breast cancer and rheumatoid arthritis, respectively. So far, the mechanisms which are responsible for ...
Complexes of macrocycles with pendant arms as models for biological molecules
(Elsevier, 2000)
Recent literature results on inorganic models related to metalloenzymes which transport electrons or activate small molecules are discussed in this review. The molecular systems are essentially restricted to macrocyclic ...
Association Models for Binding of Molecules to Nanostructures
(Royal Society of Chemistry, 2017-06)
The interaction between nanoparticles and molecules plays a key role in determining the activity and performance of a given nanostructure. These interactions are pivotal for a variety of applications including drug delivery, ...
Prevalence of COVID-19 among patients with chronic inflammatory rheumatic diseases treated with biologic agents or small molecules: A population-based study in the first two months of COVID-19 outbreak in Italy
Objective: The aim of this study is to determine the prevalence of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) among adult patients treated with biologic agents
or small molecules ...