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Mostrando ítems 1-10 de 23
Noninfectious complications in patients with pediatric-onset common variable immunodeficiency correlated with defects in somatic hypermutation but not in class-switch recombination
(Mosby-Elsevier, 2017-03)
Background Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by impaired immunoglobulin production and usually presents with a normal quantity of peripheral B cells. Most attempts aiming to ...
Sequence similarities of protein kinase substrates and inhibitors with immunoglobulins and model immunoglobulin homologue: Cell adhesion molecule from the living fossil sponge Geodia cydonium. Mapping of coherent database similarities and implications for evolution of CDR1 and hypermutation
(Folia MicrobiologicaPrague 4República Checa, 2004)
Somatic Hypermutation Defects in Common Variable Immune Deficiency
(Springer, 2017-11)
Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by impaired antibody production and recurrent infections. In the last 20 years, several groups have reported that B cells from CVID patients ...
Immunoglobulin gene rearrangements and mutational status in argentinian patients with chronic lymphocytic leukemia
(Elsevier Inc., 2013-08)
Background: Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease. The mutational status of the immunoglobulin heavy chain variable (IGHV) region represents one of the best prognostic markers and defines ...
Investigação de novas abordagens em sistemas imunes artificiais para otimização
(Universidade Federal de Minas GeraisUFMG, 2010-04-06)
The computational cost of the optimization process of electromagnetic devices is directly related to the number of objective function evaluations. This has motivated the study of new methods that are capable of determining ...
Autoimmunity in Hyper-IgM syndrome
(SPRINGER/PLENUM PUBLISHERS, 2008)
Introduction Immunodeficiency with hyper-IgM (HIGM) results from genetic defects in the CD40-CD40 ligand (CD40L) pathway or in the enzymes required for immunoglobulin class switch recombination and somatic hypermutation. ...
The Antigen Receptor as a Driver of B-Cell Lymphoma Development and Evolution
(2017)
The expression of a functional antigen receptor is necessary for cell survival of normal B lymphocytes and most B-cell neoplasms alike. When the genetic modifications of the B-cell receptor locus fail to produce a functional ...
Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia
(American Society of Hematology, 2019-05-13)
Activation-induced cytidine deaminase (AID) initiates somatic hypermutation and class switch recombination of the immunoglobulin genes. As a trade-off for its physiological function, AID also contributes to tumor development ...
Desenvolvimento de uma metodologia computacional para análise de variantes gênicas no locus de cadeia pesada de imunoglobulinas humanas
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em BioinformaticaUFMG, 2022-07-20)
The B and T cells of the adaptive immune response of humans and other vertebrates have an enormous diversity of receptors. The diversity of these receptors is generated by some processes such as: variability of the ...