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Signaling cascades transmit information downstream and upstream but unlikely simultaneously
(BioMed Central, 2016-08)
Background: Signal transduction is the process through which cells communicate with the external environment, interpret stimuli and respond to them. This mechanism is controlled by signaling cascades, which play the role ...
Long Signaling Cascades Tend to Attenuate Retroactivity
(Cell Press, 2011-04)
Signaling pathways consisting of phosphorylation/dephosphorylation cycles with no explicit feedback allow signals to propagate not only from upstream to downstream but also from downstream to upstream due to retroactivity ...
Retroactive Signaling in Short Signaling Pathways
(Public Library of Science, 2012-07)
In biochemical signaling pathways without explicit feedback connections, the core signal transduction is usually described as a one-way communication, going from upstream to downstream in a feedforward chain or network of ...
Intrinsic Feedbacks in MAPK Signaling Cascades Lead to Bistability and Oscillations
(Springer, 2013-02)
Previous studies have demonstrated that double phosphorylation of a protein can lead to bistability if some conditions are fulfilled. It was also shown that the signaling behavior of a covalent modification cycle can be ...
Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations
(Public Library of Science, 2017-06)
Ultrasensitive response motifs, capable of converting graded stimuli into binary responses, are well-conserved in signal transduction networks. Although it has been shown that a cascade arrangement of multiple ultrasensitive ...
Adaptive filtering in cascade form using a fast multichannel RLS algorithm
(Ieee-inst Electrical Electronics Engineers IncNew York, 1997)