Artículos de revistas
Intrinsic Feedbacks in MAPK Signaling Cascades Lead to Bistability and Oscillations
Fecha
2013-02Registro en:
Sepulchre, Jacques Alexandre; Ventura, Alejandra; Intrinsic Feedbacks in MAPK Signaling Cascades Lead to Bistability and Oscillations; Springer; Acta Biotheoretica; 61; 1; 2-2013; 59-78
0001-5342
1572-8358
CONICET Digital
CONICET
Autor
Sepulchre, Jacques Alexandre
Ventura, Alejandra
Resumen
Previous studies have demonstrated that double phosphorylation of a protein can lead to bistability if some conditions are fulfilled. It was also shown that the signaling behavior of a covalent modification cycle can be quantitatively and, more importantly, qualitatively modified when this cycle is coupled to a signaling pathway as opposed to being isolated. This property was named retroactivity. These two results are studied together in this paper showing the existence of interesting phenomena—oscillations and bistability—in signaling cascades possessing at least one stage with a double-phosphorylation cycle as in MAPK cascades.