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Mostrando ítems 1-10 de 21
Leviserpin: A Serine Peptidase Inhibitor (Serpin) from the Sugarcane Weevil Sphenophorus levis
(Springer, 2011-08-01)
Serine peptidase inhibitors (serpins) form a superfamily of proteins covering abroad spectrum of different biological functions. Here we describe the inhibitory characterization of leviserpin, the first serpin from the ...
Inhibition of cysteine proteinases by autolytic digestion is mediated by CBP2/Hsp47
(Taylor & Francis LtdAbingdonInglaterra, 2002)
Serpin mechanism of hepatitis C virus nonstructural 3 (NS3) protease inhibition - Induced fit as a mechanism for narrow specificity
(Amer Soc Biochemistry Molecular Biology Inc, 2004-03-12)
Hepatitis C virus (HCV) nonstructural 3 (NS3) serine protease disrupts important cellular antiviral signaling pathways and plays a pivotal role in the proteolytic maturation of the HCV polyprotein precursor. This recent ...
Increasing transcriptome response of serpins during the ontogenetic stages in the salmon louse Caligus rogercresseyi (Copepoda: Caligidae)
(2014)
Serine protease inhibitors, or serpins, target serine proteases, and are important regulators of intra- and extracellular proteolysis. For parasite survival, parasite-derived protease inhibitors have been suggested to play ...
Serpina1 hepatocyte-specific promoter polymorphism associate with chronic obstructive pulmonary disease in a study of kashmiri ancestry individuals
(Springer, 2018-08)
Different mutations in coding and non-coding sequences of the SERPINA1 gene have been implicated in the pathogenesis of COPD. However, - 10T/C mutation in the hepatocyte-directed promoter region has not been associated ...
Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates
(Amer Soc Biochemistry Molecular Biology Inc, 2002-10-18)
Human neutrophil elastase (HNE) has long been linked to the pathology of a variety of inflammatory diseases and therefore is a potential target for therapeutic intervention. At least two other serine proteases, proteinase ...
Inibidores de Proteases Oriundas de Plantas: Uma Abordagem Útil para o Desenvolvimento de Novos FármacosProteases Inhibitors Originated from Plants: Useful Approach for Development of New Drug
(Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde., 2016)