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Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer
(BioScientifica, 2020-01)
Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy without effective therapeutic options to improve survival. Steroid receptor coactivator-3 (SRC-3) is a transcriptional coactivator whose amplification and/or ...
The steroid receptor co-activator-1 (SRC-1) potentiates TGF-β/Smad signaling: role of p300/CBP
(Nature Publishing Group, 2005-01)
The three related 160-kDa proteins, SRC-1, TIF-2 and RAC-3, were initially identi•ed as factors interacting with nuclear receptors. They have also been reported to potentiate the activity of other transcription factors ...
Progesterone upregulates GATA-1 on erythroid progenitors cells in liquid culture
(Academic Press Inc Elsevier ScienceSan DiegoEUA, 2002)
Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
(Genetics and Molecular Biology, 2013-03-04)
The PPARγ nuclear receptor regulates the expression of genes involved in lipid and carbohydrate metabolism, and it has protective effects in some patients with type 2 diabetes. Nevertheless, the therapeutic value of the ...
Mapeamento de cofatores SRC1, NCoR e REA nos testículos, dúctulos eferentes e próstata de ratos
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MORFOLOGIAPrograma de Pós-Graduação em Biologia CelularUFMG, 2018-03-28)
The male genital system is controlled by sex steroid hormones, among them androgens and estrogens. Their biological effects are mediated by the androgen (AR) and estrogen (ERα and ERβ) receptors, members of the nuclear ...
Prenatal exposure to bisphenol A promotes angiogenesis and alters steroid-mediated responses in the mammary glands of cycling rats
(Pergamon-Elsevier Science Ltd, 2011-10)
Prenatal exposure to BPA disturbs mammary gland histoarchitecture and increases thecarcinogenic susceptibility to chemical challenges administered long after BPA exposure.Our aim was to assess the effect of prenatal BPA ...
Receptores estrogênicos regulam a migração e a invasão das células de câncer prostático independentes de andrógenos Pc-3
(Universidade Federal de São Paulo (UNIFESP), 2018-11-28)
Recent studies from our laboratory have shown the expression of estrogen
receptors ESR1 (ERα) and ESR2 (ERβ) in androgenindependent
prostate cancer cells
(PC3),
used as castrationresistant
prostate cancer models. ...
Estudio de las interacciones del receptor de andrógenos con sus correguladores en células de próstata humana
(30/06/2009)
ABSTRACT: Tissue recombination experiments show that prostate mesenchyma directs prostate epithelial cell growth and development in an androgen-dependent manner, and that functional differentiation of prostate epithelium ...
Progestin drives breast cancer growth by inducing p21CIP1 expression through the assembly of a transcriptional complex among Stat3, progesterone receptor and ErbB-2
(Elsevier, 2013-06-30)
Cell cycle regulator p21CIP1 has controversial biological effects in breast cancer since in spite of its role as cell cycle inhibitor and promoter of cellular senescence, it also induces cell proliferation and chemoteraphy ...