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Footprints of a trypanosomatid RNA world: pre-small subunit rRNA processing by spliced leader addition trans-splicing
(FUNDACO OSWALDO CRUZRIO DE JANEIRO, 2013-08-02)
The addition of a capped mini-exon [spliced leader (SL)] through trans-splicing is essential for the maturation of RNA polymerase (pol) II-transcribed polycistronic pre-mRNAs in all members of the Trypanosomatidae family. ...
The carboxy terminal domain of RNA polymerase II and alternative splicing
(Cell Press, 2010-09)
Alternative splicing is controlled by cis-regulatory sequences present in the pre-mRNA and their cognate trans-acting factors, as well as by its coupling to RNA polymerase II (pol II) transcription. A unique feature of ...
The largest subunit of the RNA polymerase II of Trypanosoma cruzi lacks the repeats in the carboxy-terminal domain and is encoded by several genes
(Elsevier B.V., 2003-09-01)
The largest subunit of eukaryotic RNA polymerase II (RNA Pol II) of several members of Kinetoplastida order and other early diverging eukaryote contains a serine, tyrosine and proline-rich domain in the carboxyl-terminal ...
GSK-3 is an RNA polymerase II phospho-CTD kinase
(Oxford University Press, 2020-05)
We have previously found that UV-induced DNA damage causes hyperphosphorylation of the carboxy terminal domain (CTD) of RNA polymerase II (RNAPII), inhibition of transcriptional elongation and changes in alternative splicing ...
La respuesta transcripcional y de splicing alternativo al daño al ADN y el rol de la glucógeno sintasa kinasa 3 (GSK-3)The transcriptional and alternative splicing response to DNA damage and the role of glycogen synthase kinase 3 (GSK-3)
(2019-03-25)
En esta tesis doctoral estudiamos la respuesta transcripcional y de splicing alternativo (SA) al daño al ADN producido por luz ultravioleta (UV) en células humanas en cultivo. Los CPDs, lesiones en el ADN producidas por ...
Virulencia, respuesta inmune in vivo y transcriptómica de Mycobacterium tuberculosis genotipo Beijing circulante en Colombia
(Universidad Nacional de ColombiaInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Ciudad de MéxicoBogotá - Medicina - Doctorado en Ciencias BiomédicasFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá, 2021-07-27)
La tuberculosis (TB) continúa siendo un grave problema de salud pública mundial. En Colombia, el linaje mas prevalente es el Euroamericano. El aumento de la circulación del genotipo Beijing en el territorio nacional, el ...
Estudio molecular de pacientes colombianos afectados por enanismo esencial
(Universidad del RosarioMaestría en Ciencias con Énfasis en Genética HumanaFacultad de medicina, 2017)
Microcephalic primordial dwarfism syndromes are a group of rare monogenic diseases that are characterized primarily by extreme low stature of prenatal onset and severe microcephaly. In patients who participated in the ...