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The C-terminal end of P proteins mediates ribosome inactivation by trichosanthin but does not affect the pokeweed antiviral protein activity
(Academic Press Inc Elsevier Science, 2008-05)
Ribosome inactivating proteins (RIPs) inhibit protein synthesis depurinating a conserved residue in the sarcin/ricin loop of ribosomes. Some RIPs are only active against eukaryotic ribosomes, but other RIPs inactivate with ...
Convergent evolution led ribosome inactivating proteins to interact with ribosomal stalk
(Elsevier, 2012-01)
Ribosome-inactivating proteins (RIPs) inhibit protein synthesis by depurinating an adenine on the sarcin–ricin loop (SRL) of the large subunit ribosomal RNA. Several RIPs interact with the C-terminal end of ribosomal stalk ...
Trypanosoma cruzi: High ribosomal resistance to trichosanthin inactivation
(Academic Press Inc Elsevier Science, 2008-03)
Trypanosoma cruzi is the parasite causing Chagas Disease. Several results already published suggest that T. cruzi ribosomes have remarkable differences with their mammalian counterparts. In the present work, we showed that ...
Revising the Taxonomic Distribution, Origin and Evolution of Ribosome Inactivating Protein Genes
(Public Library of Science, 2013-07)
Ribosome inactivating proteins are enzymes that depurinate a specific adenine residue in the alpha-sarcin-ricin loop of the large ribosomal RNA, being ricin and Shiga toxins the most renowned examples. They are widely ...
Metazoan Ribosome Inactivating Protein encoding genes acquired by Horizontal Gene Transfer
(Nature Publishing Group, 2017-12)
Ribosome inactivating proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine residue in the conserved sarcin/ricin loop of 28S rRNA. These enzymes are widely distributed among plants and their presence ...
Characterization of horizontally acquired ribotoxin encoding genes and their transcripts in Aedes aegypti
(Elsevier Science, 2020-09)
Ribosome Inactivating Proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine residue in the conserved sarcin/ricin loop of the 28S rRNA. The occurrence of RIP genes has been described in a wide range of ...
Whitefly genomes contain ribotoxin coding genes acquired from plants
(Nature Publishing Group, 2020-12)
Ribosome inactivating proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine residue in the conserved sarcin/ricin loop of 28S rRNA. These enzymes are widely distributed among plants and bacteria. ...
Immunological response in mice bearing LM3 breast tumor undergoing Pulchellin treatment
(Biomed Central Ltd., 2012-07-24)
Background: Ribosome-inactivating proteins (RIP) have been studied in the search for toxins that could be used as immunotoxins for cancer treatment. Pulchellin, a type 2 RIP, is suggested to induce immune responses that ...