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Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions
(Elsevier Science London, 2015-06)
Pathogen linear motif mimics are highly evolvable elements that facilitate rewiring of host protein interaction networks. Host linear motifs and pathogen mimics differ in sequence, leading to thermodynamic and structural ...
ADAN: a database for prediction of protein–protein interaction of modular domains mediated by linear motifs
(Oxford University Press, 2009-09)
Motivation: Most of the structures and functions of proteome globular domains are yet unknown. We can use high-resolution structures from different modular domains in combination with automatic protein design algorithms ...
Computational prediction of short linear motifs from protein sequences
(Springer, 2015-01)
Short Linear Motifs (SLiMs) are functional protein microdomains that typically mediate interactions between a short linear region in one protein and a globular domain in another. SLiMs usually occur in structurally disordered ...
Interactions between RNA-binding proteins and P32 homologues in trypanosomes and human cells
(Springer, 2016-02)
RNA-binding proteins (RBPs) are involved in many aspects of mRNA metabolism such as splicing, nuclear export, translation, silencing, and decay. To cope with these tasks, these proteins use specialized domains such as the ...
Evaluation of the biological activity of the disintegrin-like and cysteine-rich domains of Bothropasin, a metalloproteinase from Bothrops jararaca
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2021-05-17)
Bothropasin is a 48kDa hemorrhagic class III Snake Venom Metalloproteinase (SVMP). As a multi-domain protein, it contains catalytic metalloproteinase (M), disintegrin-like (D), and cysteine rich domains (C). Integrins ...
Interplay between sequence, structure and linear motifs in the adenovirus E1A hub protein
(Academic Press Inc Elsevier Science, 2018-12)
E1A is the main transforming protein in mastadenoviruses. This work uses bioinformatics to extrapolate experimental knowledge from Human adenovirus serotype 5 and 12 E1A proteins to all known serotypes. A conserved domain ...
Relevance of CARC and CRAC Cholesterol-Recognition Motifs in the Nicotinic Acetylcholine Receptor and Other Membrane-Bound Receptors
(Elsevier Academic Press Inc, 2017-07)
Cholesterol is a ubiquitous neutral lipid, which finely tunes the activity of a wide range of membrane proteins, including neurotransmitter and hormone receptors and ion channels. Given the scarcity of available X-ray ...
Plant homeodomain-leucine zipper I transcription factors exhibit different functional AHA motifs that selectively interact with TBP or/and TFIIB
(Springer, 2014-06)
Key message: Different members of the HD-Zip I family of transcription factors exhibit differential AHA-like activation motifs, able to interact with proteins of the basal transcriptional machinery. Homeodomain-leucine ...