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The prodrug approach: A successful tool for improving drug solubility
(2016-01-01)
Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their ...
Latenciação e formas avançadas de transporte de fármacos
(Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São Paulo, 2005-06-01)
O processo de modificação molecular denominado latenciação é revisto, apresentando formas avançadas no transporte de fármacos, utilizando macromoléculas como transportadores e sistemas de liberação sítio-específica como: ...
Biocatalytic approaches applied to the synthesis of nucleoside prodrugs
(Pergamon-Elsevier Science Ltd, 2015-06)
Nucleosides are valuable bioactive molecules, which display antiviral and antitumour activities. Diverse types of prodrugs are designed to enhance their therapeutic efficacy, however this strategy faces the troublesome ...
A Prodrug Approach to Improve the Physico-Chemical Properties and Decrease the Genotoxicity of Nitro Compounds
(Bentham Science Publ Ltd, 2011-11-01)
In therapeutics research, the nitro compounds are part of an important group of drugs with multiple pharmacological activities. However, in drug design, the inclusion of a nitro group in a molecule changes the physico-chemical ...
A Prodrug Approach to Improve the Physico-Chemical Properties and Decrease the Genotoxicity of Nitro Compounds
(Bentham Science Publ Ltd, 2011-11-01)
In therapeutics research, the nitro compounds are part of an important group of drugs with multiple pharmacological activities. However, in drug design, the inclusion of a nitro group in a molecule changes the physico-chemical ...
Prodrugs for the treatment of neglected diseases
(Molecular Diversity Preservation Int, 2008-03-01)
Recently, World Health Organization ( WHO) and Medicins San Frontieres (MSF) proposed a classification of diseases as global, neglected and extremely neglected. Global diseases, such as cancer, cardiovascular and mental ...
Latenciação e formas avançadas de transporte de fármacos
(Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São Paulo, 2005-06-01)
O processo de modificação molecular denominado latenciação é revisto, apresentando formas avançadas no transporte de fármacos, utilizando macromoléculas como transportadores e sistemas de liberação sítio-específica como: ...
Evaluation and synthesis of AZT prodrugs with optimized chemical stabilities: Experimental and theoretical analyses
(Royal Society of Chemistry, 2016-01)
The design of prodrugs of nucleoside reverse transcriptase inhibitors (NRTIs) constitutes a promising strategy to overcome several suboptimal pharmacotherapeutic properties of these kinds of drugs, among which zidovudine ...
Stability and plasmatic protein binding of novel zidovudine prodrugs: Targeting site ii of human serum albumin
(Elsevier Science, 2018-03)
Despite its vastly demonstrated clinical efficacy, zidovudine (AZT) exhibits several suboptimal pharmacokinetic properties. In particular, its short plasmatic half-life (t1/2 ~ 1 h) is related to its low bound fraction to ...