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Regulation of NADPH oxidase NOX4 by delta iodolactone (IL-δ) in thyroid cancer cells
(Elsevier Ireland, 2017-10)
Introduction: Iodine is not used only by the thyroid to synthesize thyroid hormones but also directly influences a number of thyroid parameters such as thyroid proliferation and function. Several iodinated lipids, ...
Modificação covalente de peptideos antimicrobianos e anticancerigenos para a melhoria de suas propriedades farmacológicas
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2019-08-16)
Following the information obtained by a rational design study, cyclic and dimeric helical stabilized analogues of the peptide Cm-p5 were synthetized. The cyclic monomer showed an increased activity in vitro ...
Identification of regions critically affecting kinetics and allosteric regulation of the Escherichia coli ADP-glucose pyrophosphorylase by modeling and pentapeptide-scanning mutagenesis
(American Society for Microbiology, 2007-07)
ADP-glucose pyrophosphorylase (ADP-Glc PPase) is the enzyme responsible for the regulation of bacterial glycogen synthesis. To perform a structure-function relationship study of the Escherichia coli ADP-Glc PPase enzyme, ...
Evaluación del efecto de la temperatura del agua en la viabilidad del grano de polen de cuatro variedades de arroz
(Universidad de Chile, 2010)
En Chile el arroz (Oryza sativa L.) se cultiva desde la región de O’Higgins a la del Biobío, en una superficie de 24.527 hectáreas, con un rendimiento promedio de 53,8 qq ha-1, inferior al rendimiento considerado óptimo ...
6 Iodo-d-lactone: A derivative of arachidonic acid with antitumor effects in HT-29 colon cancer cells
(Elsevier, 2013-04)
Background: IL-δ (5-hydroxy-6 iodo-8, 11, 14-eicosatrienoic delta lactone) an iodinated arachidonic acid (AA) derivative, is one of the iodolipids biosynthesized by the thyroid. Although IL-δ regulates several thyroid ...