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PSEN1 and PSEN2 Gene Expression in Alzheimer's Disease Brain: A New Approach
(Ios Press, 2014-01-01)
Presenilin 1 (PSEN1) and presenilin 2 (PSEN2) genes encode the major component of y-secretase, which is responsible for sequential proteolytic cleavages of amyloid precursor proteins and the subsequent formation of ...
Correction: Intracellular Calcium Deficits in Drosophila Cholinergic Neurons Expressing Wild Type or FAD-Mutant Presenilin
(2009)
Much of our current understanding about neurodegenerative diseases can be attributed to the study of inherited forms of
these disorders. For example, mutations in the presenilin 1 and 2 genes have been linked to early onset ...
The impact of different presenilin 1 and presenilin 2 mutations on amyloid pososition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain. Evidence for other phenotype-modifying factors
(Oxford University PressGrupo de Investigación Clínica en Enfermedades del Niño y del Adolescente - PediacienciasGrupo de Neurociencias de AntioquiaLondres, Inglaterra, 2022)
Familial Alzheimer’s Disease : Oxidative Stress, b-amyloid, Presenilins, and Cell Death
(ElsevierGrupo de Neurociencias de AntioquiaOxford, Inglaterra, 2023)
Familial dementia with frontotemporal features associated with Met146Val presenilin-1 mutation
(Wiley, 2013-04)
Most of the mutations in the presenilin-1 gene (PS-1) are associated with familial Alzheimer's disease (AD). However, certain examples can be associated with frontotemporal dementia (FTD). We performed a clinical evaluation ...
Changes in the Expression of the Alzheimer's Disease-Associated Presenilin Gene in Drosophila Heart Leads to Cardiac Dysfunction
(Bentham Science Publishers, 2011-04)
Mutations in the presenilin genes cause the majority of early-onset familial Alzheimers disease. Recently, presenilin mutations have been identified in patients with dilated cardiomyopathy (DCM), a common cause of heart ...
Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations
(BioMed Central, 2008-11)
BACKGROUND: Mutations in the presenilin (PSEN) genes are associated with early-onset familial Alzheimer's disease (FAD). Biochemical characterizations and comparisons have revealed that many PSEN mutations alter ...