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Models for evaluating the pharmacokinetics and pharmacodynamics for β-blockers
(Informa Healthcare, 2014-04)
Introduction: β-blocker therapy plays an important role in the treatment of various diseases, including hypertension, myocardial infarction and heart failure. Although all β-blockers shared their ability to competitively ...
Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing
(Elsevier, 2020-12-01)
SARS-CoV-2 utilizes the IMPα/β1 heterodimer to enter host cell nuclei after gaining cellular access through the ACE2 receptor. Ivermectin has shown antiviral activity by inhibiting the formation of the importin-α (IMPα) ...
Effects of dosage, comorbidities, and food on isoniazid pharmacokinetics in Peruvian tuberculosis patients
(American Society for Microbiology, 2014)
Poor response to tuberculosis (TB) therapy might be attributable to subtherapeutic levels in drug-compliant patients. Pharmacokinetic (PK) parameters can be affected by several factors, such as comorbidities or the interaction ...
Clinical Pharmacokinetics of Intra-arterial Melphalan and Topotecan Combination in Patients with Retinoblastoma
(Elsevier, 2014-04)
Purpose: To assess the antitumor activity, toxicity, and plasma pharmacokinetics of the combination of
melphalan and topotecan for superselective ophthalmic artery infusion (SSOAI) treatment of children with
retinoblas ...
Estimation of the Probability to Target Attainment to the Pharmacokinetic/ Pharmacodynamic Index of Ertapenem in Elderly Inpatients
(Association of Pharmaceutical Teachers of India (APTI), 2020)
Background: Infectious diseases are one of the most causes of hospitalization and
death in adults in the elderly and this population is prone to develop complications
and pharmacokinetic/pharmacodynamic changes. Objectives: ...
Pharmacogenetics-based population pharmacokinetic analysis of gabapentin in patients with chronic pain: Effect of OCT2 and OCTN1 gene polymorphisms
(2019-03-01)
Gabapentin (GAB) is eliminated unchanged in urine, and organic cation transporters (OCT2 and OCTN1) have been shown to play a role in GAB renal excretion. This prospective clinical study aimed to evaluate the genetic ...
Population pharmacokinetics of gabapentin in patients with neuropathic pain: Lack of effect of diabetes or glycaemic control
(2021-04-01)
Aims: Gabapentin (GBP) is widely used to treat neuropathic pain, including diabetic neuropathic pain. Our objective was to evaluate the role of diabetes and glycaemic control on GBP population pharmacokinetics. Methods: A ...
Monitoramento terapêutico e farmacocinética populacional da amicacina administrada em pacientes internados no Hospital Universitário de Santa Maria
(Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2022-09-13)
Serious infections in a hospital environment, especially in critically ill patients, continue to be a significant problem for the health systems associated with high morbidity and mortality rates. Amikacin is an important ...
Population pharmacokinetics and biodistribution of benznidazole in mice
(Oxford University Press, 2020)
Population pharmacokinetics of amikacin in neonatal intensive care unit patients
(Australasian Medical Journal Pty Ltd, 2017-03)
Background Amikacin treatment requires close monitoring of blood concentrations to increase the probability that levels achieved are both effective and safe. Aims We described population pharmacokinetics parameters of ...