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Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi
(Portland Press, 2004-02)
Compartmentalization of cAMP phosphodiesterases plays a key role in the regulation of cAMP signalling in mammals. In the present paper, we report the characterization and subcellular localization of TcPDE1, the first ...
Simultaneous quantification of GMP, AMP, cyclic GMP and cyclic AMP by liquid chromatography coupled to tandem mass spectrometry
(Elsevier Science BvAmsterdamHolanda, 2007)
Effect of Selective Phosphodiesterase Inhibitors on the Rat Eosinophil Chemotactic Response In Vitro
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz., 2020)
Population genetics of PDE4B (Phosphodiesterase-4B) in neglected native americans: implications for cancer pharmacogenetics.
(Wiley, 2022)
PDE4B (phosphodiesterase-4B) has an important role in cancer and in pharmacology of some disorders, such as inflammatory diseases. Remarkably in Native Americans, PDE4B variants are associated with acute lymphoblastic ...
PHOSPHODIESTERASE-4 INHIBITION REDUCES PROTEOLYSIS AND ATROGENES EXPRESSION IN RAT SKELETAL MUSCLES
(WILEY-BLACKWELL, 2011)
Phosphodiesterase (PDE) inhibition reduces skeletal muscle atrophy, but the underlying molecular mechanism remains unclear. We used microdialysis to investigate the effects of different PDE inhibitors on interstitial ...
A protein inhibitor of calmodulin-regulated cyclic nucleotide phosphodiesterase in amphibian ovaries
(1985)
The cytosol fraction of an extract of Xenopus laevis ovaries contains a protein inhibitor that can specifically block the activation of calmodulin-sensitive cyclic nucleotide phosphodiesterase (PDE I) found in that tissue. ...
Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site
(American Society for Biochemistry and Molecular Biology, 2014-11)
Background: PhoD family enzymes liberate phosphate from organic compounds. Results: The structure of PhoD reveals an active site with one Fe3! and two Ca2! ions. Conclusion: PhoD represents a new class of phosphatase related ...
Structural insights into the catalytic mechanism of sphingomyelinases D and evolutionary relationship to glycerophosphodiester phosphodiesterases
(Elsevier B.V., 2006-03-31)
Spider venom sphingomyelinases D catalyze the hydrolysis of sphingomyelin via an Mg2+ ion-dependent acid-base catalytic mechanism which involves two histidines. In the crystal structure of the sulfate free enzyme determined ...