info:eu-repo/semantics/article
Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site
Fecha
2014-11Registro en:
Rodriguez, Fernanda Mariana; Lillington, James E.D.; Steven, Johnson; Timmel, Christiane R.; Lea, Susan M.; et al.; Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site; American Society for Biochemistry and Molecular Biology; Journal of Biological Chemistry (online); 289; 11-2014; 30889-30899
0021-9258
CONICET Digital
CONICET
Autor
Rodriguez, Fernanda Mariana
Lillington, James E.D.
Steven, Johnson
Timmel, Christiane R.
Lea, Susan M.
Berks, Ben C.
Resumen
Background: PhoD family enzymes liberate phosphate from organic compounds. Results: The structure of PhoD reveals an active site with one Fe3! and two Ca2! ions. Conclusion: PhoD represents a new class of phosphatase related to purple acid phosphatases. Significance: The requirement of PhoD for iron ions may limit bacterial phosphate acquisition in low iron environments.