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For which infants with viral bronchiolitis could it be deemed appropriate to use albuterol, at least on a therapeutic trial basis?
(2021)
Although there is increasing evidence showing that infants with viral bronchiolitis exhibit a high degree of heterogeneity, a core uncertainty shared by many clinicians is with regard to understanding which patients are ...
A systematic review of treatment of Painful Diabetic Neuropathy by Pain Phenotype versus treatment Based on Medical comorbidities
(Frontiers Media Sa, 2017)
Background: Painful diabetic neuropathy (PDN) is a serious, polymorphic, and prevalent complication of diabetes mellitus. Most PDN treatment guidelines recommend a selection of drugs based on patient comorbidities. Despite ...
Effects of in utero androgen excess and metformin treatment on hepatic functions
(Elsevier Ireland, 2019-03)
This study aimed to evaluate the role of prenatal hyperandrogenization in liver functions and the extent of metformin as treatment. Pregnant rats were hyperandrogenized with subcutaneous testosterone (1mg/rat) between 16 ...
Understanding intellectual disability through RASopathies
(Elsevier, 2014-05)
Intellectual disability, commonly known as mental retardation in the International Classification of Disease from World Health Organization, is the term that describes an intellectual and adaptive cognitive disability that ...
Chronic bryostatin‑1 rescues autistic and cognitive phenotypes in the fragile X mice
(Nature, 2020)
Fragile X syndrome (FXS), an X-chromosome linked intellectual disability, is the leading monogenetic
cause of autism spectrum disorder (ASD), a neurodevelopmental condition that currently has no
specific drug treatment. ...
Effects of environmental perturbations during postnatal development on the phenotypic integration of the skull
(Veterinary and Human Toxicology, 2011-12)
Integration and modularity are fundamental determinants of how natural selection effects evolutionary change in complex multivariate traits. Interest in the study of the specific developmental basis of integration through ...
Part-time cancers and role of melatonin in determining their metabolic phenotype
(2021-08-01)
This brief review describes the association of the endogenous pineal melatonin rhythm with the metabolic flux of solid tumors, particularly breast cancer. It also summarizes new information on the potential mechanisms by ...
Silenciamento gênico por interferência de RNA (RNAi) de transcritos de Schistosoma mansoni
(Universidade Federal de Minas GeraisUFMG, 2009-08-06)
RNA interference (RNAi) represents the only reverse genetic method currently available for manipulating gene-specific expression in Schistosoma spp., since knockout and super-expression induction are not feasible in this ...