info:eu-repo/semantics/article
Effects of in utero androgen excess and metformin treatment on hepatic functions
Fecha
2019-03Registro en:
Abruzzese, Giselle Adriana; Heber, María Florencia; Ferrer, María José; Ferreira, Silvana Rocio; Silva, Aimé Florencia; et al.; Effects of in utero androgen excess and metformin treatment on hepatic functions; Elsevier Ireland; Molecular and Cellular Endocrinology; 491; 3-2019; 1-34
0303-7207
CONICET Digital
CONICET
Autor
Abruzzese, Giselle Adriana
Heber, María Florencia
Ferrer, María José
Ferreira, Silvana Rocio
Silva, Aimé Florencia
Motta, Alicia Beatriz
Resumen
This study aimed to evaluate the role of prenatal hyperandrogenization in liver functions and the extent of metformin as treatment. Pregnant rats were hyperandrogenized with subcutaneous testosterone (1mg/rat) between 16 and 19 of pregnancy. Prenatally hyperandrogenized (PH) female offspring displayed, at the adult life, two phenotypes; a PH irregular ovulatory phenotype (PHiov) and a PH anovulatory (PHanov) phenotype. From day 70 to the moment of sacrifice (90 days of age), 50% of the animals of each group received a daily oral dose of 50 mg/kg of metformin. We found that both PH phenotypes displayed a hepatic disruptions of insulin and glucose pathway and that metformin treatment reversed some of these alterations in a specific-phenotype manner. Our findings show, for the first time, that androgen excess in utero promotes hepatic dysfunctions and that metformin treatment is able to specifically reverse those hepatic alterations and sheds light on the possible mechanisms of metformin action.