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Ion pair stabilization effects on a series of procaine structural analogs
(ELSEVIER SCIENCE BV, 2010)
In this work, a series of 10 structural procaine analogs have been synthesized in order to investigate the structural features affecting the stability of ion pair formation and its influence on the lipophilicity of ionizable ...
Lipophilicity as a determinant of binding of procaine analogs to rat alpha(3)beta(4) nicotinic acetylcholine receptor
(WILEY-BLACKWELLHOBOKEN, 2012)
Nicotinic acetylcholine receptors (nAChRs) have been studied in detail with regard to their interaction with therapeutic and drug addiction-related compounds. Using a structureactivity approach, we have examined the ...