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Reversing the peptide sequence impacts on molecular surface behaviour
(Elsevier Science, 2016-03)
The protein's primary structure has all the information for specific protein/peptide folding and, in many cases, can define specific amphiphilic regions along molecules that are important for interaction with membranes. ...
Adsorption and insertion of polyarginine peptides into membrane pores: the trade-off between electrostatics, acid-base chemistry and pore formation energy
(Academic Press Inc Elsevier Science, 2019-09)
The mechanism that arginine-rich cell penetrating peptides (ARCPPs) use to translocate lipid membranes is not entirely understood. In the present work, we develop a molecular theory that allows to investigate the adsorption ...
The insertion of Polybia-MP1 peptide into phospholipid monolayers is regulated by its anionic nature and phase state
(Elsevier Ireland, 2017-10)
Polybia-MP1 or simply MP1 (IDWKKLLDAAKQIL-NH2) is a peptide with broad-spectrum bactericidal activity and a strong inhibitory effect against cancer cells. The aim of this work was to evaluate the effect of biophysical ...
The insertion of Polybia-MP1 peptide into phospholipid monolayers is regulated by its anionic nature and phase state
(Elsevier B.V., 2017-10-01)
Polybia-MP1 or simply MP1 (IDWKKLLDAAKQIL-NH2) is a peptide with broad-spectrum bactericidal activity and a strong inhibitory effect against cancer cells. The aim of this work was to evaluate the effect of biophysical ...
The insertion of Polybia-MP1 peptide into phospholipid monolayers is regulated by its anionic nature and phase state
(2017-10-01)
Polybia-MP1 or simply MP1 (IDWKKLLDAAKQIL-NH2) is a peptide with broad-spectrum bactericidal activity and a strong inhibitory effect against cancer cells. The aim of this work was to evaluate the effect of biophysical ...
Thermodynamics of cell penetrating peptides on lipid membranes: Sequence and membrane acidity regulate surface binding
(Royal Society of Chemistry, 2020-10)
Cell-penetrating peptides (CPPs) are molecules that traverse cell membranes and facilitate the cellular uptake of nano-sized cargoes. In this work we characterize the adsorption of amphipathic and purely cationic CPPs on ...
N-terminal acetylation of a mastoparan-like peptide enhances PE/PG segregation in model membranes
(2020-10-01)
The synthetic peptides L1A and its acetylated analog (acL1A) display potent Gram-negative bactericidal activities without being hemolytic. We have gathered evidence that the N-terminal acetylation of L1A enhances the lytic ...
Negative Dipole Potentials and Carboxylic Polar Head Groups Foster the Insertion of Cell-Penetrating Peptides into Lipid Monolayers
(American Chemical Society, 2018-03)
Cell-penetrating peptides (CPPs) are polycationic sequences of amino acids recognized as some of the most effective vehicles for delivering membrane-impermeable cargos into cells. CPPs can traverse cell membranes by direct ...
Assessing the interaction between surfactant-like peptides and lipid membranes
(Royal Soc Chemistry, 2017)
Atomistic molecular dynamics simulations were used to study the interaction of AnK peptides (with n = 3, 6 and 9) in contact with two different types of lipid membranes, DPPC and DPPG. PMF calculations and their decomposition ...
Estudio de la estabilidad termodinámica de la proteína α-quimotripsinógeno en soluciones acuosas de electrolitos fuertes
(Universidad Nacional de ColombiaBogotá - Ciencias - Doctorado en Ciencias - QuímicaDepartamento de QuímicaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá, 2021)
La estabilidad termodinámica del α-quimotripsinógeno A, a pH 2,00, 3,00, 3,50 y en soluciones acuosas de los electrolitos NaCl, KCl, NH4NO3 y (NH4)2SO4 fue analizada por espectroscopía UV-Vis, calorimetría diferencial de ...