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Phylogenetic conservation of protein-lipid motifs in pentameric ligand-gated ion channels
(Elsevier Science, 2015-07)
Using the crosstalk between the nicotinic acetylcholine receptor (nAChR) and its lipid microenvironment as a paradigm, this short overview analyzes the occurrence of structural motifs which appear not only to be conserved ...
Phylogenetic conservation of protein–lipid motifs in pentameric ligand-gated ion channels
(Elsevier B.V., 2015)
Abstract: Using the crosstalk between the nicotinic acetylcholine receptor (nAChR) and its lipid microenvironment as a
paradigm, this short overviewanalyzes the occurrence of structuralmotifswhich appear not only to be ...
From hopanoids to cholesterol : molecular clocks of pentameric ligand-gated ion channels
(Elsevier, 2016)
Abstract: Pentameric ligand-gated ion channels (pLGICs) and their lipid microenvironments appear to have acquired mutually adaptive traits along evolution: 1) the three-ring architecture of their transmembrane (TM) region; ...
GABAA receptor family: overview on structural characterization
(Future Science, 2019-02-25)
The pentameric γ-aminobutyric acid type A receptors are ion channels activated by ligands, which intervene in the rapid inhibitory transmission in the mammalian CNS. Due to their rich pharmacology and therapeutic potential, ...
Nanoscale interactions between the nicotinic acetylcholine receptor and cholesterol
(Instituto de Histología y Embriología, 2021-06)
Cholesterol is a major lipid in biological membranes. It not only plays a structural role but also modulates a wide range of functional properties of neurotransmitter and hormone receptors and ion channels. The membraneembedded ...
Structure and function development during evolution of pentameric ligand gated ion channels
(Smart Science and Technology, 2016-01)
Ligand Gated Ion Channels (LGICs) are receptors widely involved in vertebrate neuronal and non-neuronal signalling as well as muscle activation. Until very recently these receptors, were only known to exist in animal cells ...
Caenorhabditis elegans serotonin-gated chloride channel MOD-1 as a novel drug target for anthelmintic therapy
(Sociedad Argentina de Biofísica, 2020)
Serotonin-gated ion channels (5-HT3) belong to the family of Cys-loop receptors, which are pentameric proteins that mediate fast synaptic transmission. In mammals, 5-HT3 are non-selective cationic channels that can be ...
Role of the cys loop and transmembrane domain in the allosteric modulation of α4β2 nicotinic acetylcholine receptors
(American Society for Biochemistry and Molecular Biology Inc., 2017)
© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathways that couple agonist binding to channel ...
Nicotinic acetylcholine receptors at the single-channel level
(Wiley Blackwell Publishing, Inc, 2018-06)
Over the past four decades, the patch clamp technique and nicotinic ACh (nACh) receptors have established an enduring partnership. Like all good partnerships, each partner has proven significant in its own right, while ...