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The paradoxical roles of inflammation during PD-1 blockade in cancer
(Elsevier, 2020-09)
Recent studies have reported paradoxical roles of inflammation in tumor immunity triggered by PD-1 checkpoint antibody (Ab) blockade. Here, we elaborate on this controversy and propose a new perspective that might help ...
The Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers
(2022-03-01)
The Epstein-Barr Virus (EBV) is a gammaherpesvirus involved in the etiopathogenesis of a variety of human cancers, mostly of lymphoid and epithelial origin. The EBV infection participates in both cell transformation and ...
Immune Checkpoint Blockade via PD-L1 Potentiates More CD28-Based than 4-1BB-Based Anti-Carbonic Anhydrase IX Chimeric Antigen Receptor T Cells
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2023)
Targeted therapy to annihilate the immune-evading phenotype in cancer evolution
(Informa Healthcare, 2018-07)
Cancer is a moving target, and targeted therapy must ultimatelydeal with the evolution of the disease. This is becauseevolution is the substrate for development of resistance totargeted therapy. A successful therapeutic ...
Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of severe gastrointestinal and hepatic toxicities from checkpoint inhibitors
(Springer, 2020-12)
Immune-related adverse events (IrAEs) affecting the gastrointestinal (GI) tract and liver are among the most frequent and most severe inflammatory toxicities from contemporary immunotherapy. Inflammation of the colon and ...
Immunomodulatory monoclonal antibodies in combined immunotherapy trials for cutaneous melanoma
(Frontiers Media S.A., 2017-08)
In the last few years, there has been a twist in cancer treatment toward immunotherapy thanks to the impressive results seen in advanced patients from several tumor pathologies. Cutaneous melanoma is a highly mutated and ...
A TLR4 agonist improves immune checkpoint blockade treatment by increasing the ratio of effector to regulatory cells within the tumor microenvironment
(Nature, 2021-07)
Brucella lumazine synthase (BLS) is a homodecameric protein that activates dendritic cells via toll like receptor 4, inducing the secretion of pro-inflammatory cytokines and chemokines. We have previously shown that BLS ...
Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown
(National Academy of Sciences, 2022)
Variants in Epithelial-Mesenchymal Transition and Immune Checkpoint Genes Are Associated With Immune Cell Profiles and Predict Survival in Non-Small Cell Lung Cancer
(Coll Amer Pathologists, 2020-10-01)
Context.-Identification of gene mutations that are indicative of epithelial-mesenchymal transition and a noninflammatory immune phenotype may be important for predicting response to immune checkpoint inhibitors. Objective.-To ...